Evidence map›Paper›PMID 36458518›Full record

ArticleThe British journal of clinical psychology2023

Pathways from developmental vulnerabilities in early childhood to schizotypy in middle childhood.

Kirstie O'Hare, Oliver Watkeys, Johanna C Badcock, Kristin R Laurens, Stacy Tzoumakis, Kimberlie Dean, Felicity Harris, Vaughan J Carr, Melissa J Green

Open access · hybridAbstract read
In one paragraph

Article in The British journal of clinical psychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kirstie O'HareDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-1166-9792
Oliver WatkeysDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Johanna C BadcockSchool of Psychological Science, University of Western Australia, Perth, WA, Australia.
Kristin R LaurensDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Stacy TzoumakisDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Kimberlie DeanDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Felicity HarrisDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Vaughan J CarrDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Melissa J GreenDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-9361-4874
The University of Sydney · AUGriffith University · AUThe University of Western Australia · AU

Funding

Australian Research Council LP110100150Discovery Early Career Researcher Award DE210100113Discovery Project DP170101403Future Fellowship FT170100294Investigator Grant APP1175408National Health and Medical Research Council (NHMRC) Project APP1058652National Health and Medical Research Council (NHMRC) Project APP1148055NSW Department of Communities and JusticeNSW Department of EducationNSW Ministry of HealthPartnership Project APP1133833
6 · The paper itself

Abstract

objectivesChildhood disturbances in social, emotional, language, motor and cognitive functioning, and schizotypy have each been implicated as precursors of schizophrenia-spectrum disorders. We investigated whether relationships between early childhood developmental vulnerabilities and childhood schizotypy are mediated by educational underachievement in middle childhood.

methodsParticipants were members of a large Australian (n = 19,216) population cohort followed longitudinally. Path analyses were used to model relationships between developmental vulnerabilities at age ~5 years, educational underachievement from ages ~8 to 10 years and three distinct profiles of schizotypy at age ~11 years (true, introverted and affective schizotypy).

resultsEarly childhood developmental vulnerabilities on five broad domains (related to physical, emotional, social, cognitive and communication development) were associated with schizotypy profiles in middle childhood. Educational underachievement in middle childhood was associated with all schizotypy profiles, but most strongly with the true schizotypy profile (OR = 3.92, 95% CI = 3.12, 4.91). The relationships between schizotypy profiles and early childhood developmental vulnerabilities in 'language and cognitive skills (school-based)' and 'communication skills and general knowledge' domains were fully mediated by educational underachievement in middle childhood, and the relationships with early childhood 'physical health and well-being' and 'emotional maturity' domains were partially mediated.

conclusionDevelopmental continuity from early childhood developmental vulnerabilities to schizotypy in middle childhood is mediated by educational underachievement in middle childhood. While some domains of early developmental functioning showed differential relationships with distinct schizotypy profiles, these findings support a developmental pathway to schizotypy in which cognitive vulnerability operates from early childhood through to middle childhood.

Indexed as

SchizophreniaSchizotypal Personality DisorderAustraliaChildChild DevelopmentChild, PreschoolEmotionsHumanscognitive vulnerabilitydevelopmental antecedentspath analysisschizophrenia-spectrum disordersschizotaxiaschizotypy

Identifiers

PMID36458518
PMCPMC10946562
OpenAlexW4310594221

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.