Evidence map›Paper›PMID 36458456›Full record

ArticleEuropean journal of immunology2023

Single-cell fate mapping reveals widespread clonal ignorance of low-affinity T cells exposed to systemic infection.

Justin Leube, Anton Mühlbauer, Immanuel Andrä, Madleen Biggel, Dirk H Busch, Lorenz Kretschmer, Veit R Buchholz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Justin LeubeInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Anton MühlbauerInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Immanuel AndräInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Madleen BiggelInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Dirk H BuschInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Lorenz KretschmerInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Veit R BuchholzInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.

Funding

European Research Council 949719European Research Council StartingGrant-949719-SCIMAP
6 · The paper itself

Abstract

T cell ignorance is a specific form of immunological tolerance. It describes the maintenance of naivety in antigen-specific T cells in vivo despite the presence of their target antigen. It is thought to mainly play a role during the steady state, when self-antigens are presented in absence of costimulatory signals and at low density or to T cells of low affinity. In how far antigen-specific T cells can also remain clonally ignorant to foreign antigens, presented in the inflammatory context of systemic infection, remains unclear. Using single-cell in vivo fate mapping and high throughput flow cytometric enrichment, we find that high-affinity antigen-specific CD8

Indexed as

AutoantigensCD8-Positive T-LymphocytesCell DifferentiationImmune ToleranceAutoantigenssingle-cell fate mappingT cell ignoranceT cell receptor affinityT cell recruitmentT cell tolerance

Identifiers

PMID36458456
PMCPMC7614329

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.