Evidence map›Paper›PMID 36458433›Full record

ArticleCancer discovery2022

TNF Receptors Choose HSC Fate in Supporting Dnmt3a-Mutant Clonal Hematopoiesis.

Katia E Niño, Eric M Pietras

Open access · bronzeAbstract readEditorialComment
PubMed Publisher
In one paragraph

Article in Cancer discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Katia E NiñoDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-6576-6002
Eric M PietrasDivision of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-7339-8828
University of Colorado Anschutz Medical Campus · US

Funding

Impact of IL-1 signaling on hematopoietic stem cell function and emergence of clonal hematopoiesis.R01DK119394 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI PIETRAS, ERIC M · 2019 to 2023
$2.0M
NIDDK NIH HHS R01 DK119394
6 · The paper itself

Abstract

summaryTNFα receptor signaling distinctly promotes self-renewal and lymphoid differentiation in Dnmt3a-mutant hematopoietic stem cells, contributing to clonal hematopoiesis of indeterminate potential. See related article by SanMiguel et al., p. 2763 (3).

Indexed as

Clonal HematopoiesisTumor Necrosis Factor-alphaCell DifferentiationHematopoietic Stem CellsHumansReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alpha

Identifiers

PMID36458433
OpenAlexW4310702749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.