ArticleFrontiers in neuroscience2022
The analgesic effect of different interactive modes of virtual reality: A prospective functional near-infrared spectroscopy (fNIRS) study.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Neuroplasticity Mechanism of Stroke Rehabilitation Training System Based on Virtual Reality: A Review.Sensors (Basel, Switzerland) · 2026Pooled it
- Cortical Activation and Functional Connectivity Response to Different Interactive Modes of Virtual Reality (VR)-Induced Analgesia: A Prospective Functional Near-Infrared Spectroscopy (fNIRS) Study.Journal of pain research · 2025Trial
- Investigation of brain activation and functional connectivity characteristics following tennis-induced acute fatigue: evidence from fNIRS.European journal of applied physiology · 2026Article
- Virtual Reality-Based Pain Modulation in Subacute Musculoskeletal Injury: Functional Near-Infrared Spectroscopy Study of Neural and Behavioral Correlates.JMIR serious games · 2026Article
- Modulation of Brain Activity in Patients with Acute Non-Specific Low Back Pain by Wentong Guan Therapy: A Functional Near-Infrared Spectroscopy Study.Journal of pain research · 2026Article
- Functional brain connectivity correlates of pain relief during virtual reality exposure in cancer patients.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Working Memory Load-Dependent Cortical Mechanism of Distraction Analgesia in Healthy Individuals: An fNIRS Study.Journal of pain research · 2025Article
- Twelve-month results for a randomized sham-controlled effectiveness trial of an in-home skills-based virtual reality program for chronic low back pain.Pain reports · 2024Article
- Virtual Reality in Acute and Chronic Pain Medicine: An Updated Review.Current pain and headache reports · 2024Review
- iVR-fNIRS: studying brain functions in a fully immersive virtual environment.Neurophotonics · 2024Review
- Features of virtual reality impact effectiveness of VR pain alleviation therapeutics in pediatric burn patients: A randomized clinical trial.PLOS digital health · 2024Article
- Sociodemographic Predictors of Clinical Effectiveness, Therapeutic Program Engagement, and Device Usability for an In-Home Virtual Reality Program for Chronic Low Back Pain: Secondary Analysis of a Randomized Controlled Trial.Journal of medical extended reality · 2024Article
- Perspective: The Promise of Virtual Reality as an Immersive Therapeutic.Journal of medical extended reality · 2024Article
- Cortical activity associated with focal muscle vibration applied directly to the affected forearm flexor muscle in post-stroke patients: an fNIRS study.Frontiers in neuroscience · 2023Article
- Synergistic neuroplasticity from synchronous Taiji Yunshou and tDCS in stroke: an fNIRS study of cortical activation and cross-subject hemodynamic brain network.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virtual reality has demonstrated its analgesic effectiveness. However, its optimal interactive mode for pain relief is yet unclear, with rare objective measurements that were performed to explore its neural mechanism. Objective: This study primarily aimed at investigating the analgesic effect of different VR interactive modes Methods: Fifteen healthy volunteers (Age: 21.93 ± 0.59 years, 11 female, 4 male) were enrolled in this prospective study. Three rounds of interactive mode, including active mode, motor imagery (MI) mode, and passive mode, were successively facilitated under consistent noxious electrical stimuli (electrical intensity: 23.67 ± 5.69 mA). Repeated-measures of analysis of variance (ANOVA) was performed to examine its pain relief status and cortical activation, with Results: A larger analgesic effect on the active (-1.4(95%CI, -2.23 to -0.57), Conclusion: Our findings suggest that VR can be considered as an effective non-invasive approach for pain relief by modulating cortical pain processing. A better analgesic effect can be obtained by exciting and integrating cortical ROIs in charge of motor and cognitive functions. The interactive mode can be easily tailored to be in line with the client's characteristics, in spite of the diverse cortical activation status when an equivalent analgesic effect can be obtained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.