ArticleFrontiers in immunology2022
Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Differential effects of SARS-CoV-2-targeted infection of ATII, club cells, and macrophages on lung immunopathology and antiviral responses.Mucosal immunology · 2026Article
- Comprehensive Analysis of the Impact of Weight Loss Thresholds on Mouse Models of Fatal Viral Infection.Viruses · 2025Article
- Article
- Severe Acute Respiratory Syndrome Coronavirus 2 Variant Infection Dynamics and Pathogenesis in Transgenic K18-hViruses · 2025Article
- Squaraine-Peptide Conjugates as Efficient Reporters of Neutrophil Extracellular Traps-Mediated Chronic Inflammation.ACS applied materials & interfaces · 2025Article
- Article
- Neuropathological lesions in intravenous BCG-stimulated K18-hACE2 mice challenged with SARS-CoV-2.Veterinary research · 2024Article
- Effects of sEH inhibition on the eicosanoid and cytokine storms in SARS-CoV-2-infected mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Generation and characterization of a humanized ACE2 mouse model to study long-term impacts of SARS-CoV-2 infection.Journal of medical virology · 2024Article
- Renin-Angiotensin System and Sex Differences in COVID-19: A Critical Assessment.Circulation research · 2023Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
41 authors at 8 institutions in 1 country.
Sung-Hee KimSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Jiseon KimSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Ji Yun JangDivision of Cancer Biology, Research Institute, National Cancer Center, Goyang, Gyeonggi, South Korea.
Hyuna NohKorea Mouse Phenotyping Center, Seoul National University, Seoul, South Korea.
Jisun ParkDepartment of Life Science, Ewha Womans University, Seoul, South Korea.
Haengdueng JeongSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Donghun JeonSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Chanyang UhmSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Heeju OhSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Kyungrae ChoSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Yoon JeonDivision of Cancer Biology, Research Institute, National Cancer Center, Goyang, Gyeonggi, South Korea.
Dain OnKorea Mouse Phenotyping Center, Seoul National University, Seoul, South Korea.
Suhyeon YoonKorea Mouse Phenotyping Center, Seoul National University, Seoul, South Korea.
Soo-Yeon LimKorea Mouse Phenotyping Center, Seoul National University, Seoul, South Korea.
Sol Pin KimKorea Mouse Phenotyping Center, Seoul National University, Seoul, South Korea.
Youn Woo LeeDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Hui Jeong JangDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
In Ho ParkSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Jooyeon OhDepartment of Microbiology, Yonsei University College of Medicine, Seoul, South Korea.
Jung Seon SeoSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Jeong Jin KimSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Sang-Hyuk SeokDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea.
Yu Jin LeeDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea.
Seung-Min HongLaboratory of Avian Diseases, BK21 plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Se-Hee AnLaboratory of Avian Diseases, BK21 plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Seo Yeon KimPreclinical Research Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
Young Been KimPreclinical Research Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
Ji-Yeon HwangPreclinical Research Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
Hyo-Jung LeeDepartment of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, South Korea.
Hong Bin KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
Kang-Seuk ChoiLaboratory of Avian Diseases, BK21 plus Program for Veterinary Science and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Jun Won ParkDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea.
Jun-Young SeoSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Jun-Won YunLaboratory of Veterinary Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.
Jeon-Soo ShinSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Ho-Young LeeDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Kyoungmi KimDepartment of Physiology and Biomedical Science, Korea University College of Medicine, Seoul, South Korea.
Daekee LeeDepartment of Life Science, Ewha Womans University, Seoul, South Korea.
Ho LeeDivision of Cancer Biology, Research Institute, National Cancer Center, Goyang, Gyeonggi, South Korea.
Ki Taek NamSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
Je Kyung SeongKorea Mouse Phenotyping Center, Seoul National University, Seoul, South Korea.
Seoul National University · KRYonsei University · KREwha Womans University · KRKangwon National University · KRSeoul National University Bundang Hospital · KRDongguk University · KRKorea University · KRNational Cancer Center · KR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike protein infects the host by binding to angiotensin-converting enzyme 2 (ACE2) expressed on the cell surface, which is then processed by type II transmembrane serine protease. However, ACE2 does not react to SARS-CoV-2 in inbred wild-type mice, which poses a challenge for preclinical research with animal models, necessitating a human ACE2 (hACE2)-expressing transgenic mouse model. Cytokeratin 18 (
Indexed as
Angiotensin-Converting Enzyme 2COVID-19Alveolar Epithelial CellsAnimalsDisease Models, AnimalHumansMiceMice, TransgenicSARS-CoV-2Angiotensin-Converting Enzyme 2hACE2 transgenic miceK18-hACE2 mice modelSARS-CoV-2SCGB1A1-hACE2 mice modelSFTPB-hACE2 mice model
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.