Evidence map›Paper›PMID 36457990›Full record

ArticleArchives of medical science : AMS2022

The diagnostic potential of novel biomarkers of hypertension in men.

Angelika E Charkiewicz, Marzena Garley, Wioletta Ratajczak-Wrona, Ewa Jabłońska, Wojciech Miltyk, Joanna Motyka, Wioleta J Omeljaniuk

Open access · goldAbstract read
In one paragraph

Article in Archives of medical science : AMS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  8. Cadmium Toxicity and Health Effects-A Brief Summary.Molecules (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Angelika E CharkiewiczDepartment of Public Health Medical, University of Bialystok, Bialystok, Poland.
Marzena GarleyDepartment of Immunology, Medical University of Bialystok, Bialystok, Poland.
Wioletta Ratajczak-WronaDepartment of Immunology, Medical University of Bialystok, Bialystok, Poland.
Ewa JabłońskaDepartment of Immunology, Medical University of Bialystok, Bialystok, Poland.
Wojciech MiltykDepartment of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Bialystok, Poland.
Joanna MotykaDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland.
Wioleta J OmeljaniukDepartment of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Bialystok, Poland.
Medical University of Białystok · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, and CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies. Methods: We present the data of men with normal blood pressure, diagnosed hypertension, confirmed hypertension, and hypertension and coexisting coronary artery disease. Results: Elevated levels of miR-145-5p, miR-1-3p, and miR-423-5p and high levels of PCSK9, MyBPC3, and DNase 1 were observed in all groups of hypertensive men. We showed decreased levels of NOX1 and CYBb, and an elevated level of NCF2. Conclusions: PCSK9 shows the greatest potential as an early biomarker of screening-detected hypertension.

Indexed as

biomarkershypertensionmicroRNAneutrophil extracellular trapsneutrophils

Identifiers

PMID36457990
PMCPMC9710276
OpenAlexW4308471302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.