Evidence map›Paper›PMID 36457855›Full record

ArticleIBRO neuroscience reports2022

Subjective cognitive impairment is related to work status in people with multiple sclerosis.

J van Wegen, E E A van Egmond, R H B Benedict, E A C Beenakker, J J J van Eijk, S T F M Frequin, K de Gans, O H H Gerlach, D A M van Gorp, G J D Hengstman and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Work Difficulties in People with Multiple Sclerosis.Journal of occupational rehabilitation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 3 countries.

J van WegenAmsterdam UMC, location Vrije Universiteit Medisch Centrum, Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
E E A van EgmondLeiden University, Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden, the Netherlands.
R H B BenedictUniversity at Buffalo, Department of Neurology, New York, United States.
E A C BeenakkerMedical Centre Leeuwarden, Department of Neurology, Leeuwarden, the Netherlands.
J J J van EijkJeroen Bosch Hospital, Department of Neurology, 's-Hertogenbosch, the Netherlands.
S T F M FrequinSt. Antonius Hospital, Department of Neurology, Nieuwegein, the Netherlands.
K de GansGroene Hart Hospital, Department of Neurology, Gouda, the Netherlands.
O H H GerlachZuyderland Medical Centre, Department of Neurology, Sittard-Geleen, the Netherlands.
D A M van GorpUniversity of Humanistic Studies, Utrecht, the Netherlands.
G J D HengstmanUpendo MS Clinic, Boxtel, the Netherlands.
P J JongenMS4 Research Institute, Nijmegen, the Netherlands.
J J L van der KlinkTilburg University, Department of Social and Behavioral Sciences, Tranzo Scientific Center for Care and Welfare, Tilburg, the Netherlands.
M F RenemanUniversity of Groningen, University Medical Centre Groningen, Department of Community & Occupational Medicine, Groningen, the Netherlands.
W I M VerhagenCanisius-Wilhelmina Hospital, Department of Neurology, Nijmegen, the Netherlands.
H A M MiddelkoopLeiden University, Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden, the Netherlands.
L H VisserUniversity of Humanistic Studies, Utrecht, the Netherlands.
H E HulstLeiden University, Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden, the Netherlands.
K van der HieleLeiden University, Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden, the Netherlands.
Leiden University · NLUniversity Medical Center Groningen · NLAmsterdam University Medical Centers · NLCanisius-Wilhelmina Ziekenhuis · NLElisabeth-TweeSteden Ziekenhuis · NLGroene Hart Ziekenhuis · NLJeroen Bosch Ziekenhuis · NLMedisch Centrum Leeuwarden · NLNorth-West University · ZASt. Antonius Ziekenhuis · NLUniversity at Buffalo, State University of New York · USUniversity of Humanistic Studies · NLZuyderland Medisch Centrum · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Unemployment is common among people with multiple sclerosis (pwMS) and has been associated with subjective cognitive difficulties, specifically in memory, attention, and executive functioning. However, longitudinal research on subjective cognitive difficulties and employment is scarce. Objective: We investigated whether subjective cognitive impairment (SCI), based on the clinical cut-off score of the MS Neuropsychological Screening Questionnaire (MSNQ), was associated with work status and negative work events (NWE) at baseline and after 2 years. Moreover, we investigated whether four MSNQ subdomains were related to work status and NWE. Methods: 287 participants (77.4% female, median age = 42 years) completed questionnaires on subjective cognitive functioning, depression, anxiety, and fatigue, and completed the Symbol Digit Modalities Test (SDMT). After baseline comparisons, logistic regression analyses were performed, with work status and NWE at baseline, and employment change and NWE change within 2 years after baseline as dependent variables. Independent variables included SCI and the MSNQ domains. Covariates anxiety, depression, fatigue, and SDMT were added. Results: SCI, depression and anxiety were associated with work status ( Conclusion: Unemployed pwMS and pwMS with a deteriorated work status reported more cognitive difficulties after 2 years than employed pwMS or pwMS with a stable work status. In addition, depression, and anxiety were associated with work status.

Indexed as

Cognitive impairmentMultiple sclerosisSubjective cognitive difficultiesWork participationWork status

Identifiers

PMID36457855
PMCPMC9706155
OpenAlexW4308156553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.