Evidence map›Paper›PMID 36457842›Full record

ArticleJournal of clinical tuberculosis and other mycobacterial diseases2022

Distribution and frequency of common mutations in

Christine Vanlalbiakdiki Sailo, Ralte Lalremruata, Zothan Sanga, Vanlal Fela, Febiola Kharkongor, Zothankhuma Chhakchhuak, Lily Chhakchhuak, Lalnun Nemi, John Zothanzama, Nachimuthu Senthil Kumar

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Christine Vanlalbiakdiki SailoDepartment of Biotechnology, Mizoram University, Aizawl 796004, Mizoram, India.
Ralte LalremruataDepartment of Microbiology, Synod Hospital, Durtlang, Aizawl 796025, Mizoram, India.
Zothan SangaDepartment of Health and Family Welfare, Directorate of Health Services, Aizawl 796009, Mizoram, India.
Vanlal FelaDepartment of Health and Family Welfare, Directorate of Health Services, Aizawl 796009, Mizoram, India.
Febiola KharkongorDepartment of Health and Family Welfare, Directorate of Health Services, Aizawl 796009, Mizoram, India.
Zothankhuma ChhakchhuakChief Medical Administration, CMO, Department of Health and Family Welfare, Directorate of Health Services, Mamit 796441, Mizoram, India.
Lily ChhakchhuakDirectorate of Health Services, National Health Mission, Aizawl 796009, Mizoram, India.
Lalnun NemiDepartment of Pathology, Synod Hospital, Durtlang, Aizawl 796025, Mizoram, India.
John ZothanzamaDepartment of Biotechnology, Mizoram University, Aizawl 796004, Mizoram, India.
Nachimuthu Senthil KumarDepartment of Biotechnology, Mizoram University, Aizawl 796004, Mizoram, India.
Mizoram University · INSynod Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rifampicin resistance (RR) is a surrogate marker of multidrug-resistant tuberculosis. The aim of this study is to determine the frequency of the commonly mutated probes for Methods: Archived data of 13,454 Xpert MTB/RIF reports were evaluated retrospectively between 2014 and 2021. Socio-demographic and available clinical information were reviewed and analyzed for RR-TB cases only. Logistic Regression was used to analyze the parameters with respect to probe types. P-value ≤ 0.05 was considered to be statistically significant. Results: 2,894 patients had Conclusion: This study provides genetic pattern of drug resistance accountable for RR over the past years in Mizoram which will help local clinicians in the initiation of correct treatment. Also, our findings provide a baseline data on the magnitude of RR-TB within the state and identification of the residential areas can help local health authorities in planning surveillance programs to control the spread of RR-TB.

Indexed as

MizoramMycobacterium tuberculosisNortheast IndiaProbe mutationsXpert MTB/RIF

Identifiers

PMID36457842
PMCPMC9707063
OpenAlexW4309892498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.