Evidence map›Paper›PMID 36457727›Full record

ArticleOxidative medicine and cellular longevity2022

Protective Effect of Photobiomodulation against Hydrogen Peroxide-Induced Oxidative Damage by Promoting Autophagy through Inhibition of PI3K/AKT/mTOR Pathway in MC3T3-E1 Cells.

Xiaoshuang Zuo, Xinghui Wei, Cheng Ju, Xuankang Wang, Zhihao Zhang, Yangguang Ma, Zhijie Zhu, Xin Li, Zhiwen Song, Liang Luo and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. PPARγ Activates Autophagy by Suppressing the PI3K-AKT1-FOXO3 Signaling Pathway and thus Alleviates Hepatic Ischemia-Reperfusion Injury.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Xiaoshuang ZuoDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0002-6637-5724
Xinghui WeiDepartment of Orthopedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Cheng JuDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Xuankang WangDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhihao ZhangDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Yangguang MaDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhijie ZhuDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Xin LiDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhiwen SongDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Liang LuoDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Xueyu HuDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0003-0852-1196
Zhe WangDepartment of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0002-7573-1583
Xijing Hospital · CNPeople's Liberation Army 401 Hospital · CNTang Du Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photobiomodulation (PBM) has been repeatedly reported to play a major role in the regulation of osteoblast proliferation and mineralization. Autophagy is closely associated with various pathophysiological processes in osteoblasts, while its role in oxidative stress is even more critical. However, there is still no clear understanding of the mechanism of the role of autophagy in the regulation of osteoblast mineralization and apoptosis under oxidative stress by PBM. It was designed to investigate the impact of 808 nm PBM on autophagy and apoptosis in mouse preosteoblast MC3T3-E1 treated with hydrogen peroxide (H

Indexed as

CalcinosisHydrogen PeroxideAnimalsAutophagyMiceOxidative StressPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesHydrogen PeroxidePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases

Identifiers

PMID36457727
PMCPMC9708376
OpenAlexW4309692563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.