ReviewCureus2022
Marchiafava Bignami Disease: A Rare Neurological Complication of Long-Term Alcohol Abuse.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Splenial lesions of the corpus callosum: a comprehensive study on etiology, clinical presentation, radiological features, and prognostic insights.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Unraveling Dual Cognitive Disorders: A Case Report and Literature Review on Marchiafava-Bignami Disease and Possible Alzheimer's Disease.Diseases (Basel, Switzerland) · 2025Article
- A fatal case of acute Marchiafava-Bignami disease complicated by acute abdomen- a case report.International journal of emergency medicine · 2025Article
- Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations.World journal of experimental medicine · 2025Review
- Marchiafava-Bignami disease post-bariatric surgery: A case report and review of similar cases.Neurosciences (Riyadh, Saudi Arabia) · 2025Review
- An Atypical Case of Marchiafava-Bignami Disease in a Young Chronic Alcoholic: Challenges in Diagnosis and Prognosis.Cureus · 2024Article
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- Clinical analysis of Marchiafava-Bignami disease.BMC neurology · 2024Article
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- Hand knob sign in Marchiafava-Bignami disease and Wernicke's encephalopathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
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- Marchiafava-Bignami disease(MBD) involving bilateral handknob area: neuroimages.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Marchiafava-Bignami disease: Case presentation and radiological imaging.Radiology case reports · 2023Article
- Secondary Central Nervous System Demyelinating Disorders in the Elderly: A Narrative Review.Healthcare (Basel, Switzerland) · 2023Review
- Marchiafava-Bignami Disease: A Rare Association With Dysdiadochokinesia and Ataxic Gait.Cureus · 2023Article
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- Problemas ligados ao álcool em centros de emergência (PLACE)-People experiencing homelessness with alcohol-related problems in Lisbon's emergency shelters during the COVID-19 pandemic: a description and analysis of a harm reduction intervention.Frontiers in psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marchiafava Bignami disease is a demyelinating and necrotic disease of the central nervous system in chronic alcohol users and malnourished patients. The primary characteristic lesion of this disease is present in the corpus callosum in the form of its necrosis, but plenty of evidence suggests that it can also affect other parts of the brain. The main pathophysiology revolves around the consumption of alcohol and its ability to cause thiamine depletion in the body and hinder various metabolic pathways. There is also a hindrance in myelin synthesis, which further damages the signal transmission leading to an array of symptoms and signs. It is present in different degrees in patients in the form of different stages, namely acute, subacute, and chronic. The diagnosis of the disease becomes tough as the presenting symptoms are very generic and vague. Before the innovation of advanced imaging techniques, it was mainly a finding during an autopsy, but presently it can be diagnosed by a well-taken history and imaging techniques which can help to rule out other diseases having a similar clinical presentation. The gold standard for the diagnosis of the disease is using magnetic resonance imaging (MRI) techniques to visualize the lesions present in the corpus callosum and other areas, but other methods like computed tomography (CT) are also used. The prognosis of the disease is influenced by many factors, and it varies greatly. Some factors such as broad involvement of the cerebral cortex and severe disturbances in consciousness are indicative of a poor prognosis. The differential diagnosis consists of other alcohol use disorders like Wernicke's encephalopathy, neoplastic conditions, and multiple sclerosis, to mention a few. Each one should be carefully eliminated before finalizing the diagnosis. The treatment of the disease is not concrete, but evidence shows improvement with specific interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.