Evidence map›Paper›PMID 36457340›Full record

ReviewBioMed research international2022

Molecular Function of cGAS-STING in SARS-CoV-2: A Novel Approach to COVID-19 Treatment.

Maryam Moossavi, Mandana Rastegar, Seyedeh Zahra Moossavi, Milad Khorasani

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Maryam MoossaviDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Mandana RastegarDepartment of Molecular Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Seyedeh Zahra MoossaviFaculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Milad KhorasaniDepartment of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.ORCID https://orcid.org/0000-0002-8204-5872
Birjand University of Medical Sciences · IRMayo Clinic in Arizona · USShiraz University of Medical Sciences · IRUniversity of Neyshabur · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus illness 2019 is a significant worldwide health danger that began with severe acute respiratory syndrome coronavirus two infections. It is the largest pandemic of our lifetime to date, affecting millions of people and crippling economies globally. There is currently no viable therapy for this devastating condition. The fast spread of SARS-CoV-2 underlines the critical need for favorable treatments to prevent SARS-CoV-2 infection and dissemination. Regulating the upstream cytokine release might be a possible method for COVID-19 therapy. We propose that more consideration be paid to the dysregulated IFN-I release in COVID-19 and that cGAS and STING be considered therapeutic targets for avoiding cytokine storms and as critical components in host antiviral defense mechanisms.

Indexed as

COVID-19 Drug TreatmentMembrane ProteinsNucleotidyltransferasesSARS-CoV-2Cyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansPandemicsSTING ProteincGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING Protein

Identifiers

PMID36457340
PMCPMC9708357
OpenAlexW4309675270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.