Evidence map›Paper›PMID 36457261›Full record

ReviewGut and liver2023

SARS-CoV-2 Infection and Liver Disease: A Review of Pathogenesis and Outcomes.

Luke Baldelli, Thomas Marjot, Eleanor Barnes, A Sidney Barritt, Gwilym J Webb, Andrew M Moon

Open access · diamondAbstract readReview
In one paragraph

Review in Gut and liver, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  9. Review
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  11. Review
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  15. Article
  16. COVID-19 and the Liver: A Complex and Evolving Picture.Hepatic medicine : evidence and research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Luke BaldelliDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-0066-243X
Thomas MarjotOxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.ORCID 0000-0002-6542-6323
Eleanor BarnesOxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.ORCID 0000-0002-0860-0831
A Sidney BarrittDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-4200-3256
Gwilym J WebbCambridge Liver Unit, Addenbrooke's Hospital, Cambridge, UK.ORCID 0000-0002-0710-5644
Andrew M MoonDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0001-7163-2062
University of North Carolina at Chapel Hill · USUniversity of Oxford · GBAddenbrooke's Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The impact of the coronavirus disease 2019 (COVID-19) pandemic has been immense, and it continues to have lasting repercussions. While the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus primarily infects the respiratory system, other organ systems are affected, including the liver. Scientific knowledge on the role of SARS-CoV-2 infection and liver injury has evolved rapidly, with recent data suggesting specific hepatotropism of SARS-CoV-2. Moreover, additional concerns have been raised in regard to long-term liver damage, related to emerging cases of post-COVID-19 cholangiopathy and chronic cholestasis. Great effort has also been focused on studying how specific subpopulations with chronic medical conditions might be disproportionately impacted by COVID-19. One such population includes individuals with chronic liver disease (CLD) and cirrhosis, with an expanding body of research indicating these patients being particularly susceptible to adverse outcomes. In this review, we provide an updated summary on the current pathogenesis and mechanism of liver injury in the setting of SARS-CoV-2 infection, the association between health outcomes and SARS-CoV-2 infection in patients with CLD, and the unique consequences of the COVID-19 pandemic on the routine care of patients with CLD.

Indexed as

COVID-19Liver DiseasesHumansPandemicsSARS-CoV-2CirrhosisCOVID-19LiverSARS-CoV-2Tropism

Identifiers

PMID36457261
PMCPMC9840920
OpenAlexW4310597062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.