Evidence map›Paper›PMID 36457237›Full record

ArticleBritish journal of clinical pharmacology2023

Hyperbaric oxygen should be used for carbon monoxide poisoning.

Kinjal Sethuraman, Stephen R Thom

Open access · greenAbstract read
In one paragraph

Article in British journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kinjal SethuramanDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Stephen R ThomDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-3533-6124
University of Maryland, Baltimore · US

Funding

Inflammatory changes and glymphatic dysfunction in carbon monoxide neuropathologyR01NS122855 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI STEPHEN RAYMOND THOM · 2022 to 2026
$2.9M
NINDS NIH HHS R01 NS122855
6 · The paper itself

Abstract

This short review addresses the mechanisms of injury mediated by carbon monoxide (CO) and current information on efficacy of hyperbaric oxygen therapy (HBOT). Recent clinical series involving large, country-wide databases and prospective randomized trials are summarized. We conclude that there is an abundance of basic science and preclinical and clinical research supporting the use of HBOT for acute CO poisoning. With appropriate consideration for pathology and therapeutic mechanisms, HBOT at a dose of 2.5-3.0 atm absolute is a necessary treatment for this toxidrome.

Indexed as

Carbon Monoxide PoisoningHyperbaric OxygenationDatabases, FactualHumansOxygenProspective StudiesOxygencarboxyhaemoglobinneurological sequelaerandomized trialsβ2 integrins

Identifiers

PMID36457237
PMCPMC11651343
OpenAlexW4310592777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.