ArticleClinical and experimental pediatrics2022
Predictors of high-flow nasal cannula failure in pediatric patients with acute respiratory distress.
Article in Clinical and experimental pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Clinical Predictors of High-Flow Nasal Cannula Failure in Children with Acute Respiratory Illness: A Single-Center Experience.Indian journal of pediatrics · 2026Observational
- Exploratory Analysis of Bedside Variables Associated with Transition Failure in a Selected Cohort of Pediatric Patients Stepped Down from Non-Invasive Ventilation to High-Flow Nasal Cannula After Planned Extubation.Journal of clinical medicine · 2026Article
- Standardizing HFNC for bronchiolitis: a quality improvement protocol in an Italian children's hospital.European journal of pediatrics · 2026Article
- Early Prediction of High-flow Nasal Cannula Failure Using Pediatric-modified HACOR Score in Children with Acute Hypoxemic Respiratory Distress: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Tools for Monitoring Respiratory Distress in Heated Humidified High-flow Nasal Cannula in Children: How do We Score the Scores?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Observational
- Respiratory Rate Oxygenation (ROX) index as predictor of high flow nasal cannula in pediatric patients in pediatric intensive care unit.BMC pulmonary medicine · 2024Article
- ROX index as a predictor of failure of high-flow nasal cannula in infants with bronchiolitis.Scientific reports · 2024Article
- "Comparative analysis of predictors of failure for high-flow nasal cannula in bronchiolitis".PloS one · 2024Article
- [Analysis of ROX Index, ROX-HR Index, and SpOJournal of Korean Academy of Nursing · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundHeated humidified high-flow nasal cannula (HFNC) has gained popularity recently and is considered a standard respiratory support tool for pediatric patients with acute respiratory distress. However, data are limited on the bedside parameters that can predict HFNC failure in pediatric patients. PURPOSE: To evaluate the performance of SpO2/FiO2 (SF) ratio, pediatric respiratory rate-oxygenation (pROX) index, and clinical respiratory score (CRS), for predicting the HFNC outcomes.
methodsThis prospective observational study included 1- month to 15-year-old patients with acute respiratory distress who required HFNC support. The HFNC setting, vital signs, CRS, and treatment outcomes were recorded. Data were analyzed to determine the predictors of HFNC failure.
resultsEighty-two children participated in the study, 16 of whom (19.5%) did not respond to HFNC treatment (failure group). Pneumonia was the main reason for intubation (62.5%). Predictors of HFNC failure at 12 hours were: SF index ≤166 (sensitivity, 62.5%; specificity, 87.8%; area under the curve [AUC], 0.75), pROX index <132 (sensitivity, 68.7%; specificity, 84.8%; AUC, 0.77), and CRS ≥6 (sensitivity, 87.5%; specificity, 96.9%; AUC, 0.92).
conclusionThe CRS was the most accurate predictor of HFNC failure in pediatric patients. A CRS ≥ 6 at 12 hours after HFNC initiation and pROX, a newly modified parameter, are helpful indicators of HFNC failure.
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