ArticleMicrobial cell factories2022
Effective gossypol removal from cottonseed meal through optimized solid-state fermentation by Bacillus coagulans.
Article in Microbial cell factories, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Advances in Solid-State Fermentation Technology for Oilseed Meal: Strain Selection, Fermentation Strategies, and High-Value Applications.Foods (Basel, Switzerland) · 2026Review
- Research Progress in the Production of D-Lactic Acid from Renewable Resources.Foods (Basel, Switzerland) · 2026Review
- Managing Anti-Nutritional Factors in Plant-Based Feeds: Implications for Herbivore Nutrition and Production.Metabolites · 2026Review
- Optimization of the Microbial-Enzymatic Synergistic Treatment of Cottonseed Protein and Evaluation of the Nutritional Value and Antioxidant Activity of Cottonseed Peptides.Foods (Basel, Switzerland) · 2026Article
- Utilizing Lactobacillus plantarum and Bacillus coagulans enhances the microbial community formation during the anaerobic fermentation of Thinopyrum intermedium.BMC microbiology · 2026Article
- Effect of enzymatic cottonseed protein on serum biochemical profiles, slaughter performance, meat quality, and volatile flavor compounds of broilers.BMC veterinary research · 2026Article
- Fermented cotton stalks preserve colonic epithelial integrity in Hu sheep via the microbiota-metabolite-NF-κB/MLCK axis and mitigate the adverse effects of direct feeding.Frontiers in nutrition · 2026Article
- Low-temperature two-stage probiotic fermentation enhances nutrition and safety of pig liquid feed.Applied microbiology and biotechnology · 2025Article
- Improving Nutritional Quality of Peanut Meal through Solid-State Fermentation with Heyndrickxia coagulans.Applied biochemistry and biotechnology · 2025Article
- Screening of a Gossypol-Removing Yeast Strain and Characterization of Its Removal Mechanism.Microorganisms · 2025Article
- Effects of Fermentation and Enzymatic Hydrolysis of Cottonseed Protein on Rumen Fermentation Characteristics, Intestinal Barrier Function, and Hepatic Metabolism in Suckling Lambs.Animals : an open access journal from MDPI · 2025Article
- Improving nutritional quality and aflatoxin detoxification of peanut meal by co-fermentation with Weizmannia coagulans, Bacillus subtilis, and supplemented enzymes.Microbial cell factories · 2025Article
- Probiotic Fermentation of Defatted Cottonseed Meal for Sustainable Foods and Non-Food Applications.Microorganisms · 2025Review
- Anti-Nutritional Factors of Plant Protein Feeds for Ruminants and Methods for Their Elimination.Animals : an open access journal from MDPI · 2025Review
- Dephenolization Methods, Quality Characteristics, Applications, and Advancements of Dephenolized Cottonseed Protein: Review.Foods (Basel, Switzerland) · 2025Review
- Improved quality of cottonseed meal: effect of cottonseed protein isolate on growth performance, nutrient digestibility, and intestinal health in growing pigs.Journal of animal science · 2025Article
- Effects of a fermented cotton straw-apple pomace mixture on growth performance, rumen microbial community, and metabolome in beef cattle.Frontiers in microbiology · 2025Article
- Effects of replacing soybean meal with enzymolysis-fermentation compound protein feed on growth performance, apparent digestibility of nutrients, carcass traits, and meat quality in growing-finishing pigs.Journal of animal science and biotechnology · 2024Article
- Research progress on cottonseed meal as a protein source in pig nutrition: An updated review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Effective Degradation of Free Gossypol in Defatted Cottonseed Meal by Bacterial Laccases: Performance and Toxicity Analysis.Foods (Basel, Switzerland) · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCottonseed meal (CSM) is the main by-product of the cottonseed oil extraction process with high protein content, which is an important protein source for feed industry. However, CSM contains free gossypol (FG), a toxic substance that is detrimental to animal health and greatly limits its application. Microbial fermentation is currently considered to be one of the most effective methods to reduce FG and other anti-nutritional factors in CSM. Previously, yeast and bacteria species are used for degradation of FG in CSM, but showing less detoxification efficiency. Bacillus coagulans combines the properties of both lactic acid bacteria and Bacillus, producing both lactic acid and spores, and is considered a potential probiotic. In this study, we aimed to evaluate and optimize the effect of the solid-state fermentation process using a Bacillus coagulans to gossypol removal contained cottonseed meal.
results36 B. coagulans strains were isolated and found to have the ability to remove free gossypol. Through the evaluation of strains and optimization of fermentation conditions including fermentation temperature, ratio of material to water, inoculation amount, fermentation time and pH, we have established a solid-state fermentation process using a Bacillus coagulans strain S17 on CSM substrate with 1:1 of the material-to-water ratio, 15% (v/w) seed inoculation, 2% expanded corn flour, 1% bran, and 0.3%-0.8% metal irons at 40 °C for 52 h. After fermentation, the FG content in CSM was reduced from 923.80 to 167.90 mg/kg with 81.83% detoxification efficiency. Meanwhile, the crude protein content in CSM increased from 47.98 to 52.82%, and importantly, the spore concentration of strain S17 reached 1.68 × 10
conclusionThe study showed that B. coagulans have the potential strong ability to degrade free gossypol through cottonseed meal fermentation. This study presents a feasible process for improving the resource utilization rate and nutritional value of CSM via solid-state fermentation through B. coagulans S17.
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