Evidence map›Paper›PMID 36456949›Full record

ArticleBMC musculoskeletal disorders2022

Magnetic resonance imaging predictors (cartilage, osteophytes and meniscus) of prevalent and 3-year incident medial and lateral tibiofemoral knee joint tenderness and patellofemoral grind.

Eric C Sayre, Ali Guermazi, Savvas Nicolaou, John M Esdaile, Jacek A Kopec, Joel Singer, Hubert Wong, Anona Thorne, Jolanda Cibere

Open access · goldAbstract read
In one paragraph

Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Eric C SayreArthritis Research Canada, 230-2238 Yukon Street, Vancouver, BC, V5Y 3P2, Canada. esayre@arthritisresearch.ca.
Ali GuermaziRadiology, Boston University School of Medicine, Boston, MA, USA.
Savvas NicolaouRadiology, University of British Columbia, Vancouver, BC, Canada.
John M EsdaileArthritis Research Canada, 230-2238 Yukon Street, Vancouver, BC, V5Y 3P2, Canada.
Jacek A KopecArthritis Research Canada, 230-2238 Yukon Street, Vancouver, BC, V5Y 3P2, Canada.
Joel SingerSchool of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Hubert WongSchool of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Anona ThorneSchool of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Jolanda CibereArthritis Research Canada, 230-2238 Yukon Street, Vancouver, BC, V5Y 3P2, Canada.
University of British Columbia · CAResearch Canada · CABoston University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify magnetic resonance imaging (MRI) predictors (cartilage [C], osteophytes [O] and meniscus [M] scores) of prevalent and 3-year incident medial tibiofemoral (MTF) and lateral tibiofemoral (LTF) knee joint tenderness and patellofemoral (PF) grind. 

methodsPopulation-based knee pain cohort aged 40-79 was assessed at baseline (N = 255), 3- and 7-year follow-up (N = 108 × 2 = 216). COM scores were measured at 6/8/6 subregions respectively. Age-sex-BMI adjusted logistic models predicted prevalence versus relevant COM predictors (medial, lateral or patellar / trochlear groove scores). Fully adjusted models also included all relevant COM predictors. Binary generalized estimating equations models predicting 3-year incidence were also adjusted for individual follow-up time between cycles.

resultsSignificant predictors of prevalent MTF tenderness: medial femoral cartilage (fully adjusted odds ratio [aOR] 1.84; 95% confidence interval [CI] 1.11, 3.05), female (aOR = 3.05; 1.67, 5.58), BMI (aOR = 1.53 per 5 units BMI; 1.10, 2.11). Predictors of prevalent LTF tenderness: female (aOR = 2.18; 1.22, 3.90). There were no predictors of prevalent PF grind in the fully adjusted model. However, medial patellar osteophytes was predictive in the age-sex-BMI adjusted model. There were no predictors of 3-year incident MTF tenderness. Predictors of 3-year incident LTF tenderness: female (aOR = 3.83; 1.25, 11.77). Predictors of 3-year incident PF grind: lateral patellar osteophytes (aOR = 4.82; 1.69, 13.77). In the age-sex-BMI adjusted model, patellar cartilage was also a predictor.

conclusionWe explored potential MRI predictors of prevalent and 3-year incident MTF/LTF knee joint tenderness and PF grind. These findings could guide preemptive strategies aimed at reducing these symptoms in the present and future (3-year incidence).

Indexed as

MeniscusOsteophyteCartilageFemaleHumansKnee JointMagnetic Resonance ImagingLateral tibiofemoral tendernessMagnetic resonance imaging (MRI)Medial tibiofemoral tendernessOsteoarthritis (OA)Patellofemoral grind

Identifiers

PMID36456949
PMCPMC9716665
OpenAlexW4310703431

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.