Evidence map›Paper›PMID 36456837›Full record

ArticleCell and tissue banking2023

Cord blood derived NK cells activated in counter with tumor cells.

Behnaz Valipour, Ghazal Majidi, Khadijeh Dizaji Asl, Hojjatollah Nozad Charoudeh

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue banking, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Behnaz ValipourDepartment of Anatomical Sciences, Sarab Faculty of Medical Sciences, Sarab, Iran.
Ghazal MajidiStem Cell Research Centre, Tabriz University of Medical Sciences, Imam Reza St., Golgasht St., Tabriz, 5166614756, Iran.
Khadijeh Dizaji AslStem Cell Research Centre, Tabriz University of Medical Sciences, Imam Reza St., Golgasht St., Tabriz, 5166614756, Iran.
Hojjatollah Nozad CharoudehDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. nozadh@tbzmed.ac.ir.ORCID http://orcid.org/0000-0003-4883-9924
Tabriz University of Medical Sciences · IR

Funding

Drug Applied Research Center, Tabriz University of Medical Sciences 59696
6 · The paper itself

Abstract

NK cells are initially known for their ability to kill tumor cells with no prior sensitization. Production of mature and long lasting NK cells from Umbilical Cord Blood (UCB) by using cytokines could be a promising method for immunotherapy. NK cells were generated from cord blood cells using IL2, IL7, and IL15 cytokines and measured expression of CD57 and NKp46 markers. Afterward, their capacity in the elimination of malignant cells (Reh cell line) was evaluated by assessment of interferon-γ (as cytokine production sign) and CD107-a expression (as cytotoxic function symptom) using flow cytometry. Our results showed efficient NKp46 + , and CD57 + NK cells generated on day 14. Also, expression of CD107-a and IFN-γ following co-culture with Reh cell lines significantly increased in comparison to the control. Taken together, we have reported one of the best culture conditions for the generation of CD57 + NK cells with on feeder cells and showed appropriate capacity in counter reh cell lines as a target.

Indexed as

Fetal BloodKiller Cells, NaturalCoculture TechniquesCytokinesFlow CytometryCytokinesAcute lymphoblasticCD57 receptorCord bloodLeukemiaNK cells

Identifiers

PMID36456837
OpenAlexW4310506834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.