Evidence map›Paper›PMID 36456827›Full record

ArticleScientific reports2022

Genetic variants associated with glaucomatous visual field loss in primary open-angle glaucoma.

Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuki Hashimoto and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 1 country.

Fumihiko MabuchiDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. mabuchif-oph@umin.ac.jp.
Nakako MabuchiDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Yoichi SakuradaDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Seigo YoneyamaDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Kenji KashiwagiDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Zentaro YamagataDepartment of Health Sciences, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Mitsuko TakamotoDepartment of Ophthalmology, Saitama Red Cross Hospital, Chuo-ku, Saitama, Japan.
Makoto AiharaDepartment of Ophthalmology, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Takeshi IwataDivision of Molecular and Cellular Biology, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Meguro-ku, Tokyo, Japan.
Kazuki HashimotoDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Kota SatoDepartment of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Yukihiro ShigaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Toru NakazawaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Masato AkiyamaDepartment of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan.
Kazuhide KawaseYasuma Eye Clinic, Nagoya, Aichi, Japan.
Mineo OzakiOzaki Eye Hospital, Hyuga, Miyazaki, Japan.
Makoto AraieKanto Central Hospital of the Mutual Aid Association of Public School Teachers, Setagaya-ku, Tokyo, Japan.
University of Yamanashi · JPTohoku University · JPKanto Central Hospital · JPKyushu University · JPMiyata Eye Hospital · JPNagoya University · JPSaitama Red Cross Hospital · JPThe University of Tokyo · JPTokyo Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary open-angle glaucoma (POAG) is characterized by a progressive optic neuropathy with visual field loss. To investigate the genetic variants associated with visual field loss in POAG, Japanese POAG patients (n = 426) and control subjects (n = 246) were genotyped for 22 genetic variants predisposing to POAG that can be classified into those associated with intraocular pressure (IOP) elevation (IOP-related genetic variants) and optic nerve vulnerability independent of IOP (optic nerve-related genetic variants). The genetic risk score (GRS) of the 17 IOP-related and five optic nerve-related genetic variants was calculated, and the associations between the GRS and the mean deviation (MD) of automated static perimetry as an indicator of the severity of visual field loss and pattern standard deviation (PSD) as an indicator of the focal disturbance were evaluated. There was a significant association (Beta = - 0.51, P = 0.0012) between the IOP-related GRS and MD. The severity of visual field loss may depend on the magnitude of IOP elevation induced by additive effects of IOP-related genetic variants. A significant association (n = 135, Beta = 0.65, P = 0.0097) was found between the optic nerve-related, but not IOP-related, GRS and PSD. The optic nerve-related (optic nerve vulnerability) and IOP-related (IOP elevation) genetic variants may play an important role in the focal and diffuse visual field loss respectively. To our knowledge, this is the first report to show an association between additive effects of genetic variants predisposing to POAG and glaucomatous visual field loss, including severity and focal/diffuse disturbance of visual field loss, in POAG.

Indexed as

Glaucoma, Open-AngleVisual Field TestsHumansTonometry, OcularVision DisordersVisual Fields

Identifiers

PMID36456827
PMCPMC9715669
OpenAlexW4310707694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.