Evidence map›Paper›PMID 36456807›Full record

ReviewNature reviews. Neuroscience2023

A tripartite view of the posterior cingulate cortex.

Brett L Foster, Seth R Koslov, Lyndsey Aponik-Gremillion, Megan E Monko, Benjamin Y Hayden, Sarah R Heilbronner

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. The Anterior Cingulate Cortex and Prosocial Behavior toward Others in Negative State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brett L FosterDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. brett.foster@pennmedicine.upenn.edu.ORCID 0000-0002-2621-5574
Seth R KoslovDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7737-1377
Lyndsey Aponik-GremillionDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-2810-5408
Megan E MonkoDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Benjamin Y HaydenDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-7678-4281
Sarah R HeilbronnerDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.

Funding

Neural basis of behavior in freely moving macaquesR01MH125377 · NIMH · UNIVERSITY OF MINNESOTA · PI HAYDEN, BENJAMIN Y · 2021 to 2025
$3.5M
NEURONAL BASIS OF PERSISTENCER01DA038615 · NIDA · UNIVERSITY OF ROCHESTER · PI HAYDEN, BENJAMIN Y · 2015 to 2024
$3.4M
Posterior cingulate cortex and executive control of episodic memoryR01MH129439 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Brett Foster, BENJAMIN Y HAYDEN · 2022 to 2026
$3.4M
Sensory Reinstatement in Human NeocortexR01MH116914 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FOSTER, BRETT · 2018 to 2022
$2.0M
Revealing functional networks and circuits of the posteromedial cortex withanatomical connectivityR01MH118257 · NIMH · UNIVERSITY OF MINNESOTA · PI HEILBRONNER, SARAH RACHEL · 2019 to 2023
$1.9M
Multimodal dissociation of posterior cingulate cortex contributions to episodic memoryF32MH130027 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KOSLOV, SETH RYAN · 2022 to 2024
$236k
NIDA NIH HHS R01 DA038615NIMH NIH HHS F32 MH130027NIMH NIH HHS R01 MH116914NIMH NIH HHS R01 MH118257NIMH NIH HHS R01 MH125377NIMH NIH HHS R01 MH129439
6 · The paper itself

Abstract

The posterior cingulate cortex (PCC) is one of the least understood regions of the cerebral cortex. By contrast, the anterior cingulate cortex has been the subject of intensive investigation in humans and model animal systems, leading to detailed behavioural and computational theoretical accounts of its function. The time is right for similar progress to be made in the PCC given its unique anatomical and physiological properties and demonstrably important contributions to higher cognitive functions and brain diseases. Here, we describe recent progress in understanding the PCC, with a focus on convergent findings across species and techniques that lay a foundation for establishing a formal theoretical account of its functions. Based on this converging evidence, we propose that the broader PCC region contains three major subregions - the dorsal PCC, ventral PCC and retrosplenial cortex - that respectively support the integration of executive, mnemonic and spatial processing systems. This tripartite subregional view reconciles inconsistencies in prior unitary theories of PCC function and offers promising new avenues for progress.

Indexed as

Cerebral CortexGyrus CinguliAnimalsCognitionHumansMagnetic Resonance ImagingMemory

Identifiers

PMID36456807
PMCPMC10041987

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.