ArticleScientific reports2022
Anxiety symptoms and puberty interactively predict lower cingulum microstructure in preadolescent Latina girls.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review.Biological psychiatry · 2024Pooled it
- Neural Substrates of Emotion Processing and Cognitive Control Over Emotion in Youth Anxiety: An RDoC-Informed Study Across the Clinical to Nonclinical Continuum of Severity.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Trial
- Connectivity between the central executive and salience networks normalizes with exposure-focused CBT in pediatric anxiety.medRxiv : the preprint server for health sciences · 2026Article
- Neural Markers of Treatment Response in Pediatric Anxiety and PTSD.Current topics in behavioral neurosciences · 2025Review
- A preliminary study of threat-anticipatory responding in Latina youth: associations with age, anxiety, and cortical thickness.Social cognitive and affective neuroscience · 2024Article
- Caregiver experienced racism, acculturative stress, and political hostility predict anxiety in Latinx families residing in the United States.Cultural diversity & ethnic minority psychology · 2024Article
- Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls.BMC psychiatry · 2024Article
- High-resolution multi-shot diffusion imaging of structural networks in healthy neurocognitive aging.NeuroImage · 2023Article
- Higher spatial resolution diffusion-weighted imaging improves characterization of white matter disconnection in Alzheimer's disease.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Preadolescence is a period of increased vulnerability for anxiety, especially among Latina girls. Reduced microstructure (fractional anisotropy; FA) of white matter tracts between limbic and prefrontal regions may underlie regulatory impairments in anxiety. However, developmental research on the association between anxiety and white matter microstructure is mixed, possibly due to interactive influences with puberty. In a sample of 39 Latina girls (8-13 years), we tested whether pubertal stage moderated the association between parent- and child-reported anxiety symptoms and FA in the cingulum and uncinate fasciculus. Parent- but not child-reported anxiety symptoms predicted lower cingulum FA, and this effect was moderated by pubertal stage, such that this association was only significant for prepubertal girls. Neither anxiety nor pubertal stage predicted uncinate fasciculus FA. These findings suggest that anxiety is associated with disruptions in girls' cingulum white matter microstructure and that this relationship undergoes maturational changes during puberty.
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