Evidence map›Paper›PMID 36456568›Full record

ArticleNature communications2022

A self-powered ingestible wireless biosensing system for real-time in situ monitoring of gastrointestinal tract metabolites.

Ernesto De la Paz, Nikhil Harsha Maganti, Alexander Trifonov, Itthipon Jeerapan, Kuldeep Mahato, Lu Yin, Thitaporn Sonsa-Ard, Nicolas Ma, Won Jung, Ryan Burns and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 135 citations in OpenAlex.

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  8. Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026
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  16. Smart closed-loop drug delivery systems.Nature reviews bioengineering · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ernesto De la Paz *Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Nikhil Harsha Maganti *Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Alexander Trifonov *Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Itthipon Jeerapan *Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-8016-6411
Kuldeep MahatoDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Lu YinDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-5075-5263
Thitaporn Sonsa-ArdDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Nicolas MaDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Won JungDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Ryan BurnsDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-6150-4910
Amir ZarrinparDivision of Gastroenterology, University of California San Diego, La Jolla, CA, 92093, USA.
Joseph WangDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA. josephwang@ucsd.edu.ORCID 0000-0002-4921-9674
Patrick P MercierDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA. pmercier@ucsd.edu.ORCID 0000-0003-1488-5076
University of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Information related to the diverse and dynamic metabolite composition of the small intestine is crucial for the diagnosis and treatment of various diseases. However, our current understanding of the physiochemical dynamics of metabolic processes within the small intestine is limited due to the lack of in situ access to the intestinal environment. Here, we report a demonstration of a battery-free ingestible biosensing system for monitoring metabolites in the small intestine. As a proof of concept, we monitor the intestinal glucose dynamics on a porcine model. Battery-free operation is achieved through a self-powered glucose biofuel cell/biosensor integrated into a circuit that performs energy harvesting, biosensing, and wireless telemetry via a power-to-frequency conversion scheme using magnetic human body communication. Such long-term biochemical analysis could potentially provide critical information regarding the complex and dynamic small intestine metabolic profiles.

Indexed as

CommunicationGastrointestinal TractAnimalsElectric Power SuppliesGlucoseHumansSwineTelemetryGlucose

Identifiers

PMID36456568
PMCPMC9715945
OpenAlexW4310701659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.