Evidence map›Paper›PMID 36455966›Full record

SynthesisBritish journal of sports medicine2022

Risk factors for knee osteoarthritis after traumatic knee injury: a systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus.

Jackie L Whittaker, Justin M Losciale, Carsten B Juhl, Jonas Bloch Thorlund, Matilde Lundberg, Linda K Truong, Maxi Miciak, Belle Lore van Meer, Adam G Culvenor, Kay M Crossley and 3 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of sports medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 5 pooled it
31.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 5 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
  2. [2024 American Academy of Orthopaedic Surgeons (AAOS) Clinical Practice Guideline: An interpretation of the diagnosis and management of acute isolated meniscal injury].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Guideline
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Jackie L WhittakerDepartment of Physical Therapy, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada jackie.whittaker@ubc.ca.ORCID http://orcid.org/0000-0002-6591-4976
Justin M LoscialeDepartment of Physical Therapy, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-5135-1191
Carsten B JuhlDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Funen, Denmark.ORCID http://orcid.org/0000-0001-8456-5364
Jonas Bloch ThorlundDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Funen, Denmark.ORCID http://orcid.org/0000-0001-7789-8224
Matilde LundbergResearch Unit for General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Linda K TruongDepartment of Physical Therapy, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-0728-6297
Maxi MiciakRehabilitation Research Centre, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.
Belle Lore van MeerDepartment of Orthopaedic Surgery, Erasmus MC Medical University, Rotterdam, The Netherlands.
Adam G CulvenorLa Trobe Sport and Exercise Medicine Research Centre, La Trobe University School of Allied Health, Human Services and Sport, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-9491-0264
Kay M CrossleyLa Trobe Sport and Exercise Medicine Research Centre, La Trobe University School of Allied Health, Human Services and Sport, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-5892-129X
Ewa M RoosDepartment of Musculoskeletal Function and Physiotherapy, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0001-5425-2199
Stefan LohmanderDepartment of Clinical Sciences Lund, Orthopaedics, Lunds Universitet, Lund, Sweden.ORCID http://orcid.org/0000-0002-5424-9448
Marienke van MiddelkoopDepartment of General Practice, Erasmus MC Medical University, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6926-0618
University of Southern Denmark · DKUniversity of British Columbia · CAErasmus MC · NLLa Trobe University · AULund University · SEUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify and quantify potential risk factors for osteoarthritis (OA) following traumatic knee injury.

designSystematic review and meta-analyses that estimated the odds of OA for individual risk factors assessed in more than four studies using random-effects models. Remaining risk factors underwent semiquantitative synthesis. The modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach for prognostic factors guided the assessment. DATA SOURCES: MEDLINE, EMBASE, CENTRAL, SPORTDiscus, CINAHL searched from inception to 2009-2021. ELIGIBILITY: Randomised controlled trials and cohort studies assessing risk factors for symptomatic or structural OA in persons with a traumatic knee injury, mean injury age ≤30 years and minimum 2-year follow-up.

resultsAcross 66 included studies, 81 unique potential risk factors were identified. High risk of bias due to attrition or confounding was present in 64% and 49% of studies, respectively. Ten risk factors for structural OA underwent meta-analysis (sex, rehabilitation for anterior cruciate ligament (ACL) tear, ACL reconstruction (ACLR), ACLR age, ACLR body mass index, ACLR graft source, ACLR graft augmentation, ACLR+cartilage injury, ACLR+partial meniscectomy, ACLR+total medial meniscectomy). Very-low certainty evidence suggests increased odds of structural OA related to ACLR+cartilage injury (OR=2.31; 95% CI 1.35 to 3.94), ACLR+partial meniscectomy (OR=1.87; 1.45 to 2.42) and ACLR+total medial meniscectomy (OR=3.14; 2.20 to 4.48). Semiquantitative syntheses identified moderate-certainty evidence that cruciate ligament, collateral ligament, meniscal, chondral, patellar/tibiofemoral dislocation, fracture and multistructure injuries increase the odds of symptomatic OA.

conclusionModerate-certainty evidence suggests that various single and multistructure knee injuries (beyond ACL tears) increase the odds of symptomatic OA. Risk factor heterogeneity, high risk of bias, and inconsistency in risk factors and OA definition make identifying treatment targets for preventing post-traumatic knee OA challenging.

Indexed as

Anterior Cruciate Ligament InjuriesKnee InjuriesOsteoarthritis, KneeAdultCohort StudiesConsensusConsensus Statements as TopicHumansRandomized Controlled Trials as TopicRisk Factorsanterior cruciate ligamentmeniscusosteoarthritisrisk factor

Identifiers

PMID36455966
PMCPMC9726975
OpenAlexW4294316730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.