ArticleThe European respiratory journal2023
Respiratory effort during sleep and prevalent hypertension in obstructive sleep apnoea.
Article in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Home-testing devices for diagnosing obstructive sleep apnoea hypopnoea syndrome - a systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2026Pooled it
- Wearable Devices for Monitoring and Management of Comorbid Obstructive Sleep Apnea and Hypertension: Scoping Review.JMIR mHealth and uHealth · 2026Article
- From classic to cutting-edge: technological approaches to respiratory physiological signals in assessing sleep-disordered breathing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
- Factors associated with respiratory disturbance index higher than apnea-hypopnea index in patients with obstructive sleep apnea.Biomedical reports · 2026Article
- Development and External Validation of an Interpretable Machine Learning-Based Prediction Model for Depressive Symptoms in Patients With Obstructive Sleep Apnea: A Multicenter Study.Brain and behavior · 2026Article
- Development and Validation of an Explainable Machine Learning Model for Identifying Hypertension Status in Patients With Obstructive Sleep Apnea.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Respiratory effort burden measured by mandibular jaw movements as a digital marker with clinical insights in obstructive sleep apnea.Communications medicine · 2026Article
- Advances in cardiovascular risk assessment indicators in obstructive sleep apnea.Frontiers in public health · 2026Review
- Diagnostic Support in Dentistry Through Artificial Intelligence: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Holistic integrative analysis of circulatory parameters: effects of CPAP titration in patients with obstructive sleep apnea.Journal of thoracic disease · 2025Article
- Exploring the Dose-Response Relationship between Mandibular Protrusion and Respiratory Effort Burden in Oral Appliance Therapy for Obstructive Sleep Apnea.Annals of the American Thoracic Society · 2025Article
- Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.Scientific reports · 2025Article
- Enhancing artificial intelligence-driven sleep apnea diagnosis: The critical importance of input signal proficiency with a focus on mandibular jaw movements.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025Article
- Explainable Machine Learning Assists in Revealing Associations Between Polysomnographic Biomarkers and Incident Type 2 Diabetes in Men.Nature and science of sleep · 2025Article
- Causal Associations Between Obstructive Sleep Apnea and Hypertension: Evidence From a Bidirectional and Multivariable Mendelian Randomization Analysis.International journal of hypertension · 2025Article
- Up-to-date advance in the relationship between obstructive sleep apnea and heart failure: a narrative review.Sleep & breathing = Schlaf & Atmung · 2024Review
- Mandibular Jaw Movement Automated Analysis for Oral Appliance Monitoring in Obstructive Sleep Apnea: A Prospective Cohort Study.Annals of the American Thoracic Society · 2024Observational
- Regular snoring is associated with uncontrolled hypertension.NPJ digital medicine · 2024Article
- Article
- Insights on mandibular jaw movements during polysomnography in obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundMechanisms underlying blood pressure changes in obstructive sleep apnoea (OSA) are incompletely understood. Increased respiratory effort is one of the main features of OSA and is associated with sympathetic overactivity, leading to increased vascular wall stiffness and remodelling. This study investigated associations between a new measure of respiratory effort (percentage of total sleep time spent with increased respiratory effort based on measurement of mandibular jaw movements (MJM): REMOV, %TST) and prevalent hypertension in adults referred for evaluation of suspected OSA.
methodsA machine learning model was built to predict hypertension from clinical data, conventional polysomnography (PSG) indices and MJM-derived parameters (including REMOV). The model was evaluated in a training subset and a test subset.
resultsThe analysis included 1127 patients: 901 (80%) in the training subset and 226 (20%) in the test subset. The prevalence of hypertension was 31% and 30%, respectively, in the training and test subsets. A risk stratification model based on 18 input features including REMOV had good accuracy for predicting prevalent hypertension (sensitivity 0.75 and specificity 0.83). Using the Shapley additive explanation method, REMOV was the best predictor of hypertension after clinical risk factors (age, sex, body mass index and neck circumference) and time with oxygen saturation <90%, ahead of standard PSG metrics (including the apnoea-hypopnoea index and oxygen desaturation index).
conclusionThe proportion of sleep time spent with increased respiratory effort automatically derived from MJM was identified as a potential new reliable metric to predict prevalent hypertension in patients with OSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.