ArticleAging2022
White matter hyperintensity load is associated with premature brain aging.
Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Brain Age in Adult Patients With Early-Treated Phenylketonuria.Journal of inherited metabolic disease · 2026Article
- Regional brain age is decreased in children with sickle cell anemia.Blood advances · 2026Article
- Biological brain aging, cognitive-motor decline and vascular risk: a multivariate imaging analysis of 40,579 individuals.Frontiers in aging neuroscience · 2026Article
- The relationship between racial discrimination and white matter among Black older adults.Neurobiology of aging · 2025Article
- Distinct brain age gradients across the adult lifespan reflect diverse neurobiological hierarchies.Communications biology · 2025Article
- The value of radiomics features of white matter hyperintensities in diagnosing cognitive frailty: a study based on T2-FLAIR imaging.BMC medical imaging · 2025Article
- Advanced brain aging mediates the relationship between cardiovascular health and aphasia severity in chronic stroke.Aging brain · 2025Article
- Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults.Frontiers in aging neuroscience · 2025Article
- Mediating role of brain aging in the effect of white matter hyperintensities on post-stroke aphasia severity.Frontiers in aging neuroscience · 2025Article
- Longitudinal Progression of White Matter Hyperintensity Severity in Chronic Stroke Aphasia.Archives of rehabilitation research and clinical translation · 2023Article
- White matter hyperintensity load mediates the relationship between age and cognition.Neurobiology of aging · 2023Article
- Dynamic network properties of the superior temporal gyrus mediate the impact of brain age gap on chronic aphasia severity.Communications biology · 2023Article
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Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain age is an MRI-derived estimate of brain tissue loss that has a similar pattern to aging-related atrophy. White matter hyperintensities (WMHs) are neuroimaging markers of small vessel disease and may represent subtle signs of brain compromise. We tested the hypothesis that WMHs are independently associated with premature brain age in an original aging cohort.
methodsBrain age was calculated using machine-learning on whole-brain tissue estimates from T1-weighted images using the BrainAgeR analysis pipeline in 166 healthy adult participants. WMHs were manually delineated on FLAIR images. WMH load was defined as the cumulative volume of WMHs. A positive difference between estimated brain age and chronological age (BrainGAP) was used as a measure of premature brain aging. Then, partial Pearson correlations between BrainGAP and volume of WMHs were calculated (accounting for chronological age).
resultsBrain and chronological age were strongly correlated (
conclusionsWMHs are an independent factor associated with premature brain aging. This finding underscores the impact of white matter disease on global brain integrity and progressive age-like brain atrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.