Evidence map›Paper›PMID 36455748›Full record

ArticleNeurochemistry international2023

Near infrared spectroscopy detection of hemispheric cerebral ischemia following middle cerebral artery occlusion in rats.

Ardy Wong, Mohammad Iqbal Hossain Bhuiyan, Jeffrey Rothman, Kelly Drew, Kambiz Pourrezaei, Dandan Sun, Zeinab Barati

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemistry international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ardy WongDrexel University School of Biomedical Engineering, Science and Health Systems, Philadelphia, PA, USA.
Mohammad Iqbal Hossain BhuiyanDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, PA, 15260, USA; Veterans Affairs Pittsburgh Health Care System, Geriatric Research, Education and Clinical Center, Pennsylvania, PA, 15260, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX, 79968, USA.
Jeffrey RothmanGeophysical Institute, University of Alaska Fairbanks, USA.
Kelly DrewCenter for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, USA.
Kambiz PourrezaeiDrexel University School of Biomedical Engineering, Science and Health Systems, Philadelphia, PA, USA.
Dandan SunDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, PA, 15260, USA; Veterans Affairs Pittsburgh Health Care System, Geriatric Research, Education and Clinical Center, Pennsylvania, PA, 15260, USA.
Zeinab BaratiBarati Medical LLC, Fairbanks, AK, USA; Center for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, USA. Electronic address: zbarati@alaska.edu.
University of Alaska Fairbanks · USDrexel University · USThe University of Texas at El Paso · USUniversity of Pittsburgh · US

Funding

Renovation of LARS for Arctic Ground Squirrel BreedingP20GM130443 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI Maegan M Weltzin · 2019 to 2026
$16.4M
Development of the first wireless near infrared spectroscopy device for preclinical monitoring of cerebral oxygenationR43NS100174 · NINDS · BARATI MEDICAL, LLC · PI BARATI, ZEINAB · 2019 to 2020
$400k
NIGMS NIH HHS P20 GM130443NINDS NIH HHS R43 NS100174
6 · The paper itself

Abstract

Timely and sensitive in vivo estimation of ischemic stroke-induced brain infarction are necessary to guide diagnosis and evaluation of treatments' efficacy. The gold standard for estimation of the cerebral infarction volume is magnetic resonance imaging (MRI), which is expensive and not readily accessible. Measuring regional cerebral blood flow (rCBF) with Laser Doppler flowmetry (LDF) is the status quo for confirming reduced blood flow in experimental ischemic stroke models. However, rCBF reduction following cerebral artery occlusion often does not correlate with subsequent infarct volume. In the present study, we employed the continuous-wave near infrared spectroscopy (NIRS) technique to monitor cerebral oxygenation during 90 min of the intraluminal middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats (n = 8, male). The NIRS device consisted of a controller module and an optical sensor with two LED light sources and two photodiodes making up two parallel channels for monitoring left and right cerebral hemispheres. Optical intensity measurements were converted to deoxyhemoglobin (Hb) and oxyhemoglobin (HbO

Indexed as

Brain IschemiaIschemic StrokeAnimalsDisease Models, AnimalInfarction, Middle Cerebral ArteryMaleRatsRats, Sprague-DawleySpectroscopy, Near-InfraredIschemic strokeMiddle cerebral artery occlusion (MCAO)Near infrared spectroscopyOptical imaging

Identifiers

PMID36455748
PMCPMC10263189
OpenAlexW4310087075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.