Evidence map›Paper›PMID 36455371›Full record

ArticleBiosensors & bioelectronics2023

A portable elliptical dichroism spectrometer targeting secondary structural features of tumorous protein for pancreatic cancer detection.

Aaron Bauer, Santhalingam Elamurugan, Sara A Tolba, Fatima, Ejjigu Nega, Ivan T Lima, Wenjie Xia, Dali Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aaron BauerBiomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, USA.
Santhalingam ElamuruganBiomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, USA.
Sara A TolbaMaterials and Nanotechnology Program, North Dakota State University, 1410 North 14th Avenue, CIE 201, Fargo, ND, 58102, USA.
FatimaDepartment of Mathematics, Computer Science and Physics, Roanoke College, Salem, VA, 24153, USA; Department of Civil, Construction and Environmental Engineering, North Dakota State University, 1410 North 14th Avenue, CIE 201, Fargo, ND, 58102, USA.
Ejjigu NegaBiomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, USA.
Ivan T LimaDepartment of Electrical and Computer Engineering, North Dakota State University, 1411 Centennial Blvd., 101S, Fargo, ND, 58102, USA.
Wenjie XiaBiomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, USA; Materials and Nanotechnology Program, North Dakota State University, 1410 North 14th Avenue, CIE 201, Fargo, ND, 58102, USA; Department of Civil, Construction and Environmental Engineering, North Dakota State University, 1410 North 14th Avenue, CIE 201, Fargo, ND, 58102, USA.
Dali SunBiomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, USA; Department of Electrical and Computer Engineering, North Dakota State University, 1411 Centennial Blvd., 101S, Fargo, ND, 58102, USA. Electronic address: dali.sun@ndsu.edu.
North Dakota State University · USRoanoke College · US

Funding

Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
Exosomal Contents Guided Amino Acids Treatment for Pancreatic CancerR21CA270748 · NCI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI SUN, DALI · 2022 to 2023
$369k
Using the secondary structure (beta-sheet) of exosomal proteins for noninvasive pancreatic cancer detectionR03CA252783 · NCI · NORTH DAKOTA STATE UNIVERSITY · PI SUN, DALI · 2020 to 2020
$145k
NCI NIH HHS R03 CA252783NCI NIH HHS R21 CA270748NIGMS NIH HHS U54 GM128729
6 · The paper itself

Abstract

Stereochemical analysis is essential for understanding the complex function of biomolecules. Various direct and indirect approaches can be used to explore the allosteric configuration. However, the size, cost, and delicate nature of these systems limit their biomedical usage. Here, we constructed elliptical dichroism (ED) spectrometer for biomedical applications, whose performance is validated by experiment and theoretical simulation (Jones/Mueller calculus and time-dependent density-functional theory). Instead of complicated control of circular polarization, ED spectrometer adopted the absorbance of left- and right-oriented elliptically polarized light. With a simplified design, we demonstrated the potential of ED spectrometry as an alternative for secondary structural analysis of biomolecules, their conformation and chirality. It not only provides a portable, low-cost alternative to the sophisticated instruments currently used for structural analysis of biomolecules but also provides superior translational features: low sample consumption(200 μl), easy operation, and multiple working modes, for noninvasive cancer detection.

Indexed as

Biosensing TechniquesPancreatic NeoplasmsCircular DichroismHumansMolecular ConformationRefractometryCancer detectionChiropticalCircular dichroismDensity-functional theoryElliptical dichroismSpectrometerStereochemical analysis

Identifiers

PMID36455371
PMCPMC9792437
OpenAlexW4310196575

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.