Evidence map›Paper›PMID 36455298›Full record

ArticleACS chemical neuroscience2022

Observation of α-Synuclein Preformed Fibrils Interacting with SH-SY5Y Neuroblastoma Cell Membranes Using Scanning Ion Conductance Microscopy.

Christina Feng, Marisol Flores, Christina Dhoj, Adaly Garcia, Sheehan Belleca, Dana Abou Abbas, Jacob Parres-Gold, Aimee Anguiano, Edith Porter, Yixian Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Scanning ion conductance microscopy reveals differential effect of PMAnalytical and bioanalytical chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Christina FengDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Marisol FloresDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Christina DhojDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Adaly GarciaDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Sheehan BellecaDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Dana Abou AbbasDepartment of Biological Sciences, California State University, Los Angeles, Los Angeles, California 90032, United States.
Jacob Parres-GoldDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.ORCID 0000-0002-2050-0139
Aimee AnguianoDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.
Edith PorterDepartment of Biological Sciences, California State University, Los Angeles, Los Angeles, California 90032, United States.
Yixian WangDepartment of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, California 90032, United States.ORCID 0000-0001-8691-1128
California State University Los Angeles · US

Funding

UNDERGRADUATE STUDENT TRAINING IN ACADEMIC RESEARCHT34GM008228 · NIGMS · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI TUNSTAD, LINDA M. · 1986 to 2022
$13.3M
PROVIDE NEW INSIGHTS IN ALPHA-SYNUCLEIN INDUCED CELL MEMBRANE DISRUPTION USING SCANNING ION CONDUCTANCE MICROSCOPY AND SURFACE PLASMON RESONANCE MICROSCOPYR15NS120157 · NINDS · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI WANG, YIXIAN · 2020 to 2024
$847k
NIGMS NIH HHS T34 GM008228NINDS NIH HHS R15 NS120157
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second-most prevalent neurodegenerative disorder in the U.S. α-Synuclein (α-Syn) preformed fibrils (PFFs) have been shown to propagate PD pathology in neuronal populations. However, little work has directly characterized the morphological changes on membranes associated with α-Syn PFFs at a cellular level. Scanning ion conductance microscopy (SICM) is a noninvasive

Indexed as

NeuroblastomaParkinson Diseasealpha-SynucleinCell MembraneHumansMicroscopyalpha-SynucleinLDHParkinson’s diseaseprotein−lipid interactionSICMXTTα-synuclein

Identifiers

PMID36455298
PMCPMC9782390
OpenAlexW4310774476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.