Evidence map›Paper›PMID 36455190›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2023

Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.

Camryn M Cohen, Nicolas Wentzensen, Philip E Castle, Mark Schiffman, Rosemary Zuna, Rebecca C Arend, Megan A Clarke

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 5 pooled it
18.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 5 syntheses or guidelines pooled it, 133 citations in OpenAlex.

  1. Pooled it
  2. Social determinants of health in studies using PROMs to assess toxicities associated with immune checkpoint inhibitor treatment: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  15. Establishing a Cervical Cytology Biorepository: A Protocol for Advancing Translational Cervical Cancer Research through Biobanking.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
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  17. Female liver transplant recipients are at increased risk of developing cervical cancer: A global multicenter study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Camryn M CohenDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0002-7412-9910
Nicolas WentzensenDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0003-1251-0836
Philip E CastleDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0003-1082-6554
Mark SchiffmanDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.
Rosemary ZunaDepartment of Pathology, College of Medicine, University of Oklahoma, Oklahoma City, OK.
Rebecca C ArendDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL.
Megan A ClarkeDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0003-0435-7376
National Cancer Institute · USUniversity of Alabama at Birmingham · USUniversity of Oklahoma · US

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI TZYY-CHOOU WU · 2003 to 2026
$53.5M
Cervical Cancer MoonshotZIACP010230 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SCHIFFMAN, MARK · 2018 to 2025
$33.8M
CERVICAL CANCER AND HUMAN PAPILLOMAVIRUS (HPV) INFECTIONZ01CP010124 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SCHIFFMAN, MARK · 1996 to 2008
$3.0M
Intramural NIH HHS Z01 CP010124NCI NIH HHS P50 CA098252
6 · The paper itself

Abstract

purposeWe conducted an integrated population-based analysis of histologic subtype-specific cervical cancer incidence, survival, and incidence-based mortality by race and ethnicity, with correction for hysterectomy prevalence.

methodsUsing the SEER 21 and 18 registries, we selected primary cases of malignant cervical cancer diagnosed among women ≥ 15 years. We evaluated age-adjusted incidence rates among cases diagnosed between 2000 and 2018 (SEER21) and incidence-based mortality rates among deaths from 2005 to 2018 (SEER18), per 100,000 person-years. Rates were stratified by histologic subtype and race/ethnicity (incidence and mortality), and stage, age at diagnosis, and county-level measures of social determinants of health (incidence only). Incidence and mortality rates were corrected for hysterectomy using data from the Behavioral Risk Factor Surveillance System. We estimated 5-year relative survival by histologic subtype and stratified by stage at diagnosis.

resultsIncidence rates of cervical squamous cell carcinoma were highest in Black and Hispanic women, while incidence rates of cervical adenocarcinoma (ADC) were highest among Hispanic and White women, particularly for localized ADC. County-level income and education variables were inversely associated with squamous cell carcinoma incidence rates in all racial and ethnic groups but had less influence on ADC incidence rates. Black women had the highest overall mortality rates and lowest 5-year relative survival, irrespective of subtype and stage. Disparities in survival were particularly pronounced for Black women with regional and distant ADC, compared with other racial/ethnic groups.

conclusionAlthough Black women are less likely to be diagnosed with ADC compared with all other racial/ethnic groups, they experience the highest mortality rates for this subtype, likely attributed to the poor survival observed for Black women with regional and distant ADC.

Indexed as

Carcinoma, Squamous CellUterine Cervical NeoplasmsEthnicityFemaleHealth Status DisparitiesHumansIncidenceSEER ProgramUnited States

Identifiers

PMID36455190
PMCPMC9928618
OpenAlexW4310601632

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.