Evidence map›Paper›PMID 36455136›Full record

ReviewAmerican journal of Alzheimer's disease and other dementias

Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases.

Jinan Xu, Xingjiang Jin, Zuting Ye, Dandan Wang, Hang Zhao, Zhiqian Tong

Open access · goldAbstract readReview
In one paragraph

Review in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Formaldehyde induces and promotes Alzheimer's disease pathologies in a 3D human neural cell culture model.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jinan XuInstitute of Ningbo, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0003-3156-3028
Xingjiang JinKey Laboratory of Alzheimer's Disease of Zhejiang Province, 280079Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Zuting YeKey Laboratory of Alzheimer's Disease of Zhejiang Province, 280079Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Dandan WangKey Laboratory of Alzheimer's Disease of Zhejiang Province, 280079Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Hang ZhaoKey Laboratory of Alzheimer's Disease of Zhejiang Province, 280079Institute of Aging, Oujiang Laboratory, School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Zhiqian TongInstitute of Ningbo, Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-0511-0386
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most of neurodegenerative diseases (NDD) have no cure. The common etiology of neurodegenerations is unclear. Air pollutant-gaseous formaldehyde is notoriously known to induce demyelination and cognitive impairments. Unexpectedly, an amount of formaldehyde has been detected in the brains. Multiple factors can induce the generation and accumulation of endogenous formaldehyde. Excessive formaldehyde can induce oxidative stress to generate H

Indexed as

Demyelinating DiseasesNeurodegenerative DiseasesFormaldehydeHumansHydrogen PeroxideUbiquinonecoenzyme Q10FormaldehydeHydrogen PeroxideUbiquinonecoenzyme Q10demyelinationendogenous formaldehydeinflammation stormneurodegenerative diseases

Identifiers

PMID36455136
PMCPMC10624093
OpenAlexW4311115342

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.