SynthesisDiabetes care2022
Physical Activity and Risk of Major Diabetes-Related Complications in Individuals With Diabetes: A Systematic Review and Meta-Analysis of Observational Studies.
Synthesis in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Association between type 2 diabetes and site-specific fracture risk: A systematic review and meta-analysis of cohort studies including over 13 million participants.Diabetic medicine : a journal of the British Diabetic Association · 2026Pooled it
- Clinical guidelines on physical activity and exercise therapy for Chinese adults with type 2 diabetes: A clinical practice guideline from the Chinese Society of Endocrinology.Journal of sport and health science · 2026Guideline
- The use of sequential multiple assignment randomized trials (SMARTs) in physical activity interventions: a systematic review.BMC medical research methodology · 2024Pooled it
- Interventions to increase physical activity level in patients with whole spectrum chronic kidney disease: a systematic review and meta-analysis.Renal failure · 2023Pooled it
- Counseling Intervention and Cardiovascular Events in People With Peripheral Artery Disease: A Post Hoc Analysis of the BIP Randomized Clinical Trial.JAMA surgery · 2024Trial
- Effects of self-monitoring using an accelerometer on physical activity of older people with long-term care insurance in Japan: a randomized controlled trial.European geriatric medicine · 2024Trial
- Mediterranean lifestyle and risk of adverse cardiovascular events, all-cause and cardiovascular mortality among individuals with type 2 diabetes.EClinicalMedicine · 2026Article
- The effect of timing of physical exercise on glycemia: a systematic review and meta-analysis of human intervention studies.Journal of diabetes and metabolic disorders · 2026Review
- Impact of physical activity on visual outcomes among persons with type 2 diabetes: A scoping review of randomized controlled trials.Dialogues in health · 2026Review
- Intensity of physical activity and cardiovascular and all-cause mortality in diabetic patients: A cohort study (NHANES 1999-2018).Medicine · 2026Article
- Family influences on type 2 diabetes self-management: Perspectives of African American adults with food insecurity.Patient education and counseling · 2026Article
- Impact of leisure-time and daily life physical activity on chronic kidney disease in individuals with type 2 diabetes: The Fukuoka Diabetes Registry.Clinical and experimental nephrology · 2026Article
- Income and risk of type 2 diabetes incidence varied associations according to obesity status: a nationwide study.BMC public health · 2026Article
- Effects of a device-measured physical activity intervention on visual outcomes, including contrast sensitivity, and glycaemic control in individuals with abnormal glucose tolerance: a pilot randomised trial post-CarMeR study.Pilot and feasibility studies · 2026Article
- Accelerometer-derived "weekend warrior" physical activity pattern and risk of age-related eye diseases: a prospective cohort study.Eye and vision (London, England) · 2026Article
- Metabolic reprogramming in diabetes and other endocrine and metabolic disorders: exploring the Warburg effect, ketones, and SGLT2 inhibitors.Reviews in endocrine & metabolic disorders · 2026Review
- Global, regional, and national burden of major diabetes-related complications attributable to physical inactivity.Journal of sport and health science · 2026Article
- Psychological flexibility patterns in patients with type 2 diabetes mellitus and its associations with self-care behavior and medical condition.BMC psychology · 2026Article
- Impact of a 2-year structured program on physical fitness and physical activity in T2D patients with rapid renal function decline-the ACTIDIANE RCT.Frontiers in sports and active living · 2026Article
- Associations of physical activity and sedentary time with diabetic kidney disease among adults with diabetes: a multicenter population-based study.Frontiers in endocrinology · 2026Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical activity is a cornerstone in diabetes management; however, evidence synthesis on the association between physical activity and long-term diabetes-related complications is scarce. PURPOSE: To summarize and evaluate findings on physical activity and diabetes-related complications, we conducted a systematic review and meta-analysis. DATA SOURCES: We searched PubMed, Web of Science, and the Cochrane Library for articles published up to 6 July 2021. STUDY SELECTION: We included prospective studies investigating the association between physical activity and incidence of and mortality from diabetes-related complications, i.e., cardiovascular disease (CVD), coronary heart disease, cerebrovascular events, heart failure, major adverse cardiovascular events, and microvascular complications such as retinopathy and nephropathy, in individuals with diabetes. DATA EXTRACTION: Study characteristics and risk ratios with 95% CIs were extracted. Random-effects meta-analyses were performed, and the certainty of evidence and risk of bias were evaluated with use of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) and Risk Of Bias In Non-randomised Studies - of Interventions (ROBINS-I) tools. DATA SYNTHESIS: Overall, 31 studies were included. There was moderate certainty of evidence that high versus low levels of physical activity were inversely associated with CVD incidence, CVD mortality (summary risk ratio 0.84 [95% CI 0.77, 0.92], n = 7, and 0.62 [0.55, 0.69], n = 11), and microvascular complications (0.76 [0.67, 0.86], n = 8). Dose-response meta-analyses showed that physical activity was associated with lower risk of diabetes-related complications even at lower levels. For other outcomes, similar associations were observed but certainty of evidence was low or very low. LIMITATIONS: Limitations include residual confounding and misclassification of exposure.
conclusionsPhysical activity, even below recommended amounts, was associated with reduced incidence of diabetes-related complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.