Evidence map›Paper›PMID 36455068›Full record

Trial reportAmerican journal of respiratory and critical care medicine2023

Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-Containing Regimens for Drug-Sensitive Tuberculosis: 12-Week Results.

Kelly E Dooley, Bronwyn Hendricks, Nikhil Gupte, Grace Barnes, Kim Narunsky, Colleen Whitelaw, Tanya Smit, Elisa H Ignatius, Adine Friedman, Susan E Dorman and 2 more

Open access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Structural and Mechanistic Characterization ofInternational journal of molecular sciences · 2026
    Article
  5. Anti-TB Drugs for Drug-Sensitive and Drug-ResistantCurrent issues in molecular biology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. First detection of aEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  13. Promise and Peril of Pretomanid-Rifamycin Regimens for Drug-susceptible Tuberculosis.American journal of respiratory and critical care medicine · 2023
    Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Kelly E DooleyVanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0001-9013-5256
Bronwyn HendricksDivision of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa.
Nikhil GupteJohns Hopkins India Private Limited, Pune, India.
Grace BarnesSchool of Medicine, Johns Hopkins University, Baltimore, Maryland; and.
Kim NarunskyDivision of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa.
Colleen WhitelawDivision of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa.
Tanya SmitDivision of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa.
Elisa H IgnatiusSchool of Medicine, Johns Hopkins University, Baltimore, Maryland; and.
Adine FriedmanDivision of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa.
Susan E DormanMedical University of South Carolina, Charleston, South Carolina.
Rodney DawsonDivision of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa.
Assessing Pretomanid for Tuberculosis (APT) Study Team
University of Cape Town · ZAJohns Hopkins University · USMedical University of South Carolina · USVanderbilt University Medical Center · US

Funding

Phase 2 Study of PA-824 for Treatment of Pulmonary TuberculosisR01FD004794 · FDA · JOHNS HOPKINS UNIVERSITY · PI DOOLEY, KELLY E., DORMAN, SUSAN E · 2014 to 2021
$1.7M
Optimizing Anti-mycobacterial Therapy Using A Pharmacology-based ApproachK23AI159145 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Elisa Helen Ignatius · 2022 to 2026
$994k
Mentoring Investigators in HIV and Tuberculosis Therapeutics ResearchK24AI150349 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DOOLEY, KELLY E. · 2020 to 2025
$789k
FDA HHS R01 FD004794NIAID NIH HHS K23 AI159145NIAID NIH HHS K24 AI150349
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

NitroimidazolesTuberculosis, PulmonaryAntitubercular AgentsDrug Therapy, CombinationHumansIsoniazidPyrazinamideRifampinAntitubercular AgentsIsoniazidNitroimidazolespretomanidPyrazinamideRifampinphase 2 clinical trialpretomanidpyrazinamiderifamycinstuberculosis

Identifiers

PMID36455068
PMCPMC12042667
OpenAlexW4310506822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.