ArticleProceedings of the National Academy of Sciences of the United States of America2022
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Insights into X-linked Dystonia-Parkinsonism and Spinocerebellar Ataxia type 36 Through the Lens of Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.Molecular neurobiology · 2026Review
- Blocking RAN translation without altering repeat RNAs rescuesScience (New York, N.Y.) · 2026Article
- Article
- Inhibition of PolyGA Dipeptide Repeat Protein Aggregation by Nucleic Acid Aptamers in C9 Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Models.Molecular neurobiology · 2025Article
- Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics.The Lancet. Neurology · 2025Review
- CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA.The Journal of clinical investigation · 2024Article
- Dietary NMN supplementation enhances motor and NMJ function in ALS.Experimental neurology · 2024Article
- Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesis.Frontiers in molecular neuroscience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 4 institutions in 3 countries.
Melanie JambeauDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Kevin D MeyerNeurimmune AG, Schlieren CH-8952 Switzerland.ORCID 0000-0002-5774-2895
Marian Hruska-PlochanDepartment of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland.
Ricardos TabetDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Chao-Zong LeeDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Ananya Ray-SoniDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Corey AguilarDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Kitty SavageDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Nibha MishraDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Nicole CavegnNeurimmune AG, Schlieren CH-8952 Switzerland.
Petra BorterNeurimmune AG, Schlieren CH-8952 Switzerland.
Chun-Chia LinDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Karen R Jansen-WestDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.
Jie JiangLudwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093.
Fernande FreyermuthDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Nan LiDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Pierre De RossiDepartment of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland.
Manuela Pérez-BerlangaDepartment of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland.
Xin JiangDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Lilian M DaughrityDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.
João PereiraDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Sarav NarayananBiogen, Cambridge, MA 02142.
Yuanzheng GuBiogen, Cambridge, MA 02142.
Shekhar DhokaiBiogen, Cambridge, MA 02142.
Isin Dalkilic-LiddleBiogen, Cambridge, MA 02142.
Zuzanna ManieckaDepartment of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland.
Julien WeberDepartment of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland.
Michael WorkmanDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Melissa McAlonis-DownesLudwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093.
Eugene BerezovskiDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Yong-Jie ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.ORCID 0000-0001-9519-4992
James BerryDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Brian J WaingerDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Mark W KankelBiogen, Cambridge, MA 02142.
Mia RusheBiogen, Cambridge, MA 02142.
Christoph HockNeurimmune AG, Schlieren CH-8952 Switzerland.
Roger M NitschNeurimmune AG, Schlieren CH-8952 Switzerland.
Don W ClevelandLudwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.
Tania F GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.
Fabio MontrasioNeurimmune AG, Schlieren CH-8952 Switzerland.
Jan GrimmNeurimmune AG, Schlieren CH-8952 Switzerland.
Magdalini PolymenidouDepartment of Quantitative Biomedicine, University of Zurich, Zurich CH-8057 Switzerland.
Clotilde Lagier-TourenneDepartment of Neurology, The Sean M. Healey and AMG Center for ALS at the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.ORCID 0000-0002-3058-8322
University of Zurich · CHBroad Institute · USBiogen (United States) · USHarvard University · US
Funding
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1MUsing RNA signatures for therapy development in neurodegeneration due to C9orf72 expansionsR01NS087227 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LAGIER-TOURENNE, CLOTILDE · 2014 to 2018
$1.5MNIA NIH HHS P50 AG005134NINDS NIH HHS R01 NS087227
Abstract
Hexanucleotide G
Indexed as
Genes, RegulatorPoly AAnimalsAntigen-Antibody ComplexC9orf72 ProteinDipeptidesDisease Models, AnimalHumansMiceAntigen-Antibody ComplexC9orf72 ProteinC9orf72 protein, humanDipeptidesPoly Aamyotrophic lateral sclerosisC9orf72dipeptide repeat proteinsfrontotemporal dementiaimmunotherapy
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.