Evidence map›Paper›PMID 36454723›Full record

ArticleBone & joint open2022

Periprosthetic joint infection following hip hemiarthroplasty : factors associated with infection and treatment outcome.

Jonathan Bourget-Murray, Isabel Horton, Jared Morris, Antoine Bureau, Simon Garceau, Hesham Abdelbary, George Grammatopoulos

Open access · goldAbstract read
In one paragraph

Article in Bone & joint open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. MappingMicroorganisms · 2024
    Article
  10. Addition of gentamicin for antibiotic prophylaxis in hip hemiarthroplasty does not decrease the rate of surgical site infection.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jonathan Bourget-MurrayDivision of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Canada.
Isabel HortonDivision of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Canada.
Jared MorrisDivision of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Canada.
Antoine BureauDivision of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Canada.
Simon GarceauDivision of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Canada.
Hesham AbdelbaryDivision of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Canada.
George GrammatopoulosDivision of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Canada.ORCID 0000-0002-7444-9498
Ottawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aims of this study were to determine the incidence and factors for developing periprosthetic joint infection (PJI) following hemiarthroplasty (HA) for hip fracture, and to evaluate treatment outcome and identify factors associated with treatment outcome.

methodsA retrospective review was performed of consecutive patients treated for HA PJI at a tertiary referral centre with a mean 4.5 years' follow-up (1.6 weeks to 12.9 years). Surgeries performed included debridement, antibiotics, and implant retention (DAIR) and single-stage revision. The effect of different factors on developing infection and treatment outcome was determined.

resultsA total of 1,984 HAs were performed during the study period, and 44 sustained a PJI (2.2%). Multiple logistic regression analysis revealed that a higher CCI score (odds ratio (OR) 1.56 (95% confidence interval (CI) 1.117 to 2.187); p = 0.003), peripheral vascular disease (OR 11.34 (95% CI 1.897 to 67.810); p = 0.008), cerebrovascular disease (OR 65.32 (95% CI 22.783 to 187.278); p < 0.001), diabetes (OR 4.82 (95% CI 1.903 to 12.218); p < 0.001), moderate-to-severe renal disease (OR 5.84 (95% CI 1.116 to 30.589); p = 0.037), cancer without metastasis (OR 6.42 (95% CI 1.643 to 25.006); p = 0.007), and metastatic solid tumour (OR 15.64 (95% CI 1.499 to 163.087); p = 0.022) were associated with increasing PJI risk. Upon final follow-up, 17 patients (38.6%) failed initial treatment and required further surgery for HA PJI. One-year mortality was 22.7%. Factors associated with treatment outcome included lower preoperative Hgb level (97.9 g/l (SD 11.4) vs 107.0 g/l (SD 16.1); p = 0.009), elevated CRP level (99.1 mg/l (SD 63.4) vs 56.6 mg/l (SD 47.1); p = 0.030), and type of surgery. There was lower chance of success with DAIR (42.3%) compared to revision HA (66.7%) or revision with conversion to total hip arthroplasty (100%). Early-onset PJI (≤ six weeks) was associated with a higher likelihood of treatment failure (OR 3.5 (95% CI 1.2 to 10.6); p = 0.007) along with patients treated by a non-arthroplasty surgeon (OR 2.5 (95% CI 1.2 to 5.3); p = 0.014).

conclusionHA PJI initially treated with DAIR is associated with poor chances of success and its value is limited. We strongly recommend consideration of a single-stage revision arthroplasty with cemented components.Cite this article:

Indexed as

arthroplasty surgeonsCharlson Comorbidity IndexDebridement, antibiotics, and implant retentionhemiarthroplastyHemiarthroplastyHip fracturehip hemiarthroplastyinfectionsOutcomesPeriprosthetic joint infectionperiprosthetic joint infection (PJI)revision arthroplasty surgeriesSurgical site infectionSurgical strategytotal hip arthroplasty

Identifiers

PMID36454723
PMCPMC9783270
OpenAlexW4310497373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.