Evidence map›Paper›PMID 36454598›Full record

ArticleVox sanguinis2023

Systematic reviews on platelet transfusions: Is there unnecessary duplication of effort? A scoping review.

Bert Avau, Dorien O, Koen Veys, Jørgen Georgsen, Susan Nahirniak, Nadine Shehata, Simon J Stanworth, Hans Van Remoortel, Emmy De Buck, Veerle Compernolle and 1 more

Open access · bronzeAbstract readScoping Review
In one paragraph

Article in Vox sanguinis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 6 countries.

Bert AvauCentre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.ORCID https://orcid.org/0000-0002-9160-084X
Dorien OCentre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.
Koen VeysCentre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.
Jørgen GeorgsenSouth Danish Transfusion Service & Tissue Center, Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
Susan NahirniakFaculty of Medicine, University of Alberta, Edmonton, Canada.
Nadine ShehataDepartments of Medicine, Laboratory Medicine and Pathobiology, Institute of Health Policy Management and Evaluation, University of Toronto, Mount Sinai Hospital, Toronto, Canada.
Simon J StanworthTransfusion Medicine, NHS Blood and Transplant, Oxford, UK.ORCID https://orcid.org/0000-0002-7414-4950
Hans Van RemoortelCentre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.ORCID https://orcid.org/0000-0003-1942-1799
Emmy De BuckCentre for Evidence-Based Practice, Belgian Red Cross, Mechelen, Belgium.ORCID https://orcid.org/0000-0003-4498-9781
Veerle CompernolleBlood Services, Belgian Red Cross, Mechelen, Belgium.
Philippe VandekerckhoveDepartment of Public Health and Primary Care, Leuven Institute for Healthcare Policy, KU Leuven, Leuven, Belgium.
Rode Kruis-Vlaanderen · BEAlberta Environment and Protected Areas · CAGhent University · BEMount Sinai Hospital · CANHS Blood and Transplant · GBOdense University Hospital · DKWestern Cape Department of Health · ZA

Funding

European Blood Alliance 2021-01Foundation for Scientific Research of the Belgian Red Cross Structural Funding
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPlatelet transfusions are used across multiple patient populations to prevent and correct bleeding. This scoping review aimed to map the currently available systematic reviews (SRs) and evidence-based guidelines in the field of platelet transfusion. MATERIALS AND

methodsA systematic literature search was conducted in seven databases for SRs on effectiveness (including dose and timing, transfusion trigger and ratio to other blood products), production modalities and decision support related to platelet transfusion. The following data were charted: methodological features of the SR, population, concept and context features, outcomes reported, study design and number of studies included. Results were synthesized in interactive evidence maps.

resultsWe identified 110 SRs. The majority focused on clinical effectiveness, including prophylactic or therapeutic transfusions compared to no platelet transfusion (34 SRs), prophylactic compared to therapeutic-only transfusion (8 SRs), dose, timing (11 SRs) and threshold for platelet transfusion (15 SRs) and the ratio of platelet transfusion to other blood products in massive transfusion (14 SRs). Furthermore, we included 34 SRs on decision support, of which 26 evaluated viscoelastic testing. Finally, we identified 22 SRs on platelet production modalities, including derivation (4 SRs), pathogen inactivation (6 SRs), leucodepletion (4 SRs) and ABO/human leucocyte antigen matching (5 SRs). The SRs were mapped according to concept and clinical context.

conclusionAn interactive evidence map of SRs and evidence-based guidelines in the field of platelet transfusion has been developed and identified multiple reviews. This work serves as a tool for researchers looking for evidence gaps, thereby both supporting research and avoiding unnecessary duplication.

Indexed as

Platelet TransfusionThrombocytopeniaHemorrhageHumansSystematic Reviews as Topicdecision supporthaemostasisplatelet apheresisplatelet transfusionscoping reviewthrombocytopeniaviscoelastic

Identifiers

PMID36454598
PMCPMC10107266
OpenAlexW4310493651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.