ArticleForensic toxicology2022
Determination of new psychoactive substances and other drugs in postmortem blood and urine by UHPLC-MS/MS: method validation and analysis of forensic samples.
Article in Forensic toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Research hotspots and trends on illicit drugs: a bibliometric and visualized analysis.Frontiers in medicine · 2025Pooled it
- Interpol review of forensic toxicology, 2023-2025.Forensic science international. Synergy · 2026Review
- Comparison of Immunoassay Results near Cutoff Values with LC-MS/MS in Individuals with Substance Use Disorder Under Probation.Metabolites · 2026Article
- Quantification of glyphosate and glufosinate in human blood using the aqueous layer recovered from QuEChERS extraction.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- [Determination of 65 synthetic cannabinoids in whole blood by QuEChERS-ultra performance liquid chromatography- mass spectrometry].Se pu = Chinese journal of chromatography · 2026Article
- Review
- A Sensitive and Comprehensive LC-MS/MS Method for the Analysis of Hallucinogens, Synthetic Cathinones, and Synthetic Cannabinoids in Urine Samples.Journal of mass spectrometry : JMS · 2025Article
- A simple method for the determination of stimulant substances in postmortem blood: development, validation, and application in nearly 1000 forensic cases.Forensic toxicology · 2025Article
- Quantitative analysis of ΔAnalytical and bioanalytical chemistry · 2025Article
- Influence of Drugs and Toxins on Decomposition Dynamics: Forensic Implications.Molecules (Basel, Switzerland) · 2024Review
- QuEChERS Extraction and Simultaneous Quantification in GC-MS/MS of Hexahydrocannabinol Epimers and Their Metabolites in Whole Blood, Urine, and Oral Fluid.Molecules (Basel, Switzerland) · 2024Article
- LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications.Molecules (Basel, Switzerland) · 2023Review
- Analysis of Cannabinoids in Biological Specimens: An Update.International journal of environmental research and public health · 2023Review
- Analysis of 2,5-dimethoxy-amphetamines and 2,5-dimethoxy-phenethylamines aiming their determination in biological matrices: a review.Forensic toxicology · 2023Review
- A review of synthetic cathinones emerging in recent years (2019-2022).Forensic toxicology · 2023Review
- Psychoactive substances use before suicide: detailed analysis of all cases that occurred in the Brazilian Federal District in a 10-years period.BMC psychiatry · 2022Observational
- Fatal cases involving new psychoactive substances and trends in analytical techniques.Frontiers in toxicology · 2022Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to validate a modified QuEChERS method followed by ultra-high performance liquid chromatography-tandem mass spectrometry to determine 79 new psychoactive substances (NPS) and other drugs in blood and urine.
methodsPrescription drugs (n = 23), synthetic cathinones (n = 13), phenethylamines (n = 11); synthetic cannabinoids (n = 8), amphetamines (n = 7) and other psychoactive substances (n = 17) were included in the method. 500 µL of biological fluid was extracted with 2 mL of water/ACN (1:1), 500 mg of anhydrous MgSO
resultsThe method was satisfactorily validated for blood and urine at limit of quantifications ranging from 0.4 to 16 ng/mL, and applied to the analysis of 54 blood (38 postmortem and 16 antemortem) and 16 antemortem urine samples from 68 forensic cases. All urine samples and 59.3% of the blood samples were positive for at least one analyte. Twenty-two analytes were detected in at least one biological sample, including the synthetic cathinones ethylone (222 ng/mL, antemortem blood), eutylone (246 and 446 ng/mL, urine), and N-ethylpentylone (597 and 7.3 ng/mL, postmortem and antemortem blood, respectively).
conclusionsThe validated method was shown to be suitable for the analysis of blood and urine forensic samples and an important tool to collect information on emerging drug threats and understanding the impact of NPS and other drugs in poisoning cases.
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