Evidence map›Paper›PMID 36454457›Full record

ArticleAdvances in experimental medicine and biology2023

Online Databases of Genome Editing in Cardiovascular and Metabolic Diseases.

Paula Carrillo-Rodriguez, Javier Martinez-Lopez, Laura Gómez-Hernández, Luis Boraita-Morales, Maria Uceda-Molina, Irene Cuenca-Bermejo, Juan P Valencia-Aguirre, Marahy Mora-López, Julio Plaza-Diaz

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Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paula Carrillo-Rodriguez *Research and Advances in Molecular and Cellular Immunology, Center of Biomedical Research, University of Granada, Granada, Spain.
Javier Martinez-Lopez *Research and Advances in Molecular and Cellular Immunology, Center of Biomedical Research, University of Granada, Granada, Spain.
Laura Gómez-HernándezDepartment of Biochemistry and Molecular Biology III and Immunology, University of Granada, Granada, Spain.
Luis Boraita-MoralesInstituto de Parasitología y Biomedicina "López-Neyra"-CSIC, University of Granada, Granada, Spain.
Maria Uceda-MolinaResearch and Advances in Molecular and Cellular Immunology, Center of Biomedical Research, University of Granada, Granada, Spain.
Irene Cuenca-BermejoInstituto de Investigación Biosanitaria IBS, Complejo Hospitalario Universitario de Granada, Granada, Spain.
Juan P Valencia-AguirreGENYO, Centre for Genomics and Oncological Research-Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain.
Marahy Mora-LópezDepartment of Biochemistry and Molecular Biology III and Immunology, University of Granada, Granada, Spain.
Julio Plaza-DiazInstituto de Investigación Biosanitaria IBS, Complejo Hospitalario Universitario de Granada, Granada, Spain. jrplaza@ugr.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic and cardiovascular diseases are world-concerning pathologies that affect an important percentage of the population. Nowadays, advances in the genetic background of these diseases allow new approaches to models and therapies, as well as different gene edition trials. Furthermore, technological improvements in gene editing go along with the development of new online and biocomputational tools that provide us alternative ways to explore pathologies. In this chapter, historical gene editing methods are discussed but focusing on CRISPR-Cas system in detail and also online resources available to perform these types of experiments. Here, the different strategies for gene editing and their online tools are gathered, putting the light on its application in the study and treatment of cardiovascular and metabolic diseases.

Indexed as

Cardiovascular SystemMetabolic DiseasesCRISPR-Cas SystemsDatabases, FactualGene EditingHumansCardiovascular diseaseCRISPR-Cas systemsGene editingMetabolic disease

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.