Evidence map›Paper›PMID 36454438›Full record

ArticleJournal of endocrinological investigation2023

Vitamin D and chronotype: is there any relationship in individuals with obesity?

C Vetrani, L Barrea, L Verde, A Docimo, S Aprano, S Savastano, A Colao, G Muscogiuri

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In one paragraph

Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

C Vetrani *Endocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 5, Sergio Pansini, 80131, Naples, Italy.ORCID http://orcid.org/0000-0001-8335-5939
L Barrea *Centro Italiano Per La Cura E Il Benessere del Paziente Con Obesità (C.I.B.O), University of Naples "Federico II", Naples, Italy.ORCID http://orcid.org/0000-0001-9054-456X
L VerdeCentro Italiano Per La Cura E Il Benessere del Paziente Con Obesità (C.I.B.O), University of Naples "Federico II", Naples, Italy.ORCID http://orcid.org/0000-0002-4583-8283
A DocimoEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 5, Sergio Pansini, 80131, Naples, Italy.ORCID http://orcid.org/0000-0002-5394-6786
S ApranoEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 5, Sergio Pansini, 80131, Naples, Italy.
S SavastanoEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 5, Sergio Pansini, 80131, Naples, Italy.ORCID http://orcid.org/0000-0002-3211-4307
A ColaoEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 5, Sergio Pansini, 80131, Naples, Italy.ORCID http://orcid.org/0000-0001-6986-266X
G MuscogiuriEndocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 5, Sergio Pansini, 80131, Naples, Italy. giovanna.muscogiuri@gmail.com.ORCID http://orcid.org/0000-0002-8809-4931
Federico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChronotype is the attitude to perform most of the daily activities in the morning ("morning chronotype", MC) or in the evening ("evening chronotype", EC). The latter, as well as vitamin D deficiency, has been associated with an increased risk of obesity-related complications, likely through the promotion of insulin resistance. Therefore, we aimed to investigate whether there is any relationship between vitamin D (25-OH-D) and chronotype in individuals with obesity.

methodsIn this cross-sectional study, we enrolled 59 individuals (43.1 ± 13 years; 17M/42F) with obesity. Anthropometric parameters, lifestyle habits, personal medical history, chronotype, insulin resistance, and 25-OH-D were assessed.

resultsIndividuals with EC presented significantly higher BMI than MC (p < 0.001), greater waist (p = 0.012), and hip circumferences (p = 0.001). Individuals with EC showed significantly lower insulin sensitivity (p = 0.017) and 25-OH-D than MC. In addition, the prevalence of vitamin D deficiency and impaired fasting glucose was significantly higher in EC than in MC. 25-OH-D directly correlated with chronotype score (r = 0.351; p = 0.019) whereas inversely with BMI (r = - 0.363; p = 0.016). The regression analysis showed that BMI was most tightly associated with 25-OH-D concentrations (β = - 0.323, p = 0.032), followed by chronotype score (β = 0.340, p = 0.042). Using chronotype score as the dependent variable, BMI significantly predicted a lower chronotype score (β = - 0.586, p < 0.001).

conclusionThe present study showed that 25-OH-D, as well as chronotype, correlate independently with obesity.

Indexed as

Insulin ResistanceVitamin D DeficiencyBody Mass IndexChronotypeCross-Sectional StudiesHumansObesityVitamin DVitaminsVitamin DVitamins25-OH-DChronotypeInsulin resistanceObesityVitamin D

Identifiers

PMID36454438
OpenAlexW4310567874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.