ArticleJournal of assisted reproduction and genetics2023
PGT-A is associated with reduced cumulative live birth rate in first reported IVF stimulation cycles age ≤ 40: an analysis of 133,494 autologous cycles reported to SART CORS.
Article in Journal of assisted reproduction and genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does preimplantation genetic testing for aneuploidy improve live birth rate in women diagnosed with recurrent implantation failure: A systematic review and meta-analysis?Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Stage-structured, distributional prediction of IVF outcomes with conditional updating.Journal of assisted reproduction and genetics · 2026Article
- Insured Fertility Care in Japan: Can Universal Coverage Preserve a Single-Embryo-Transfer Culture?Cureus · 2026Review
- Elective single embryo transfer in in vitro fertilization cycles with or without preimplantation genetic testing using next-generation sequencing: A randomized clinical trial.Clinics (Sao Paulo, Brazil) · 2026Article
- Reclaiming 'abnormal' embryos after preimplantation genetic testing for aneuploidy: patients' perspectives on transferring embryos against prior institutional advice.Human reproduction open · 2026Article
- Association between ovarian reserve and utilization of preimplantation genetic testing for aneuploidy in autologous IVF cycles.Human reproduction open · 2026Article
- Sequencing platforms influence segmental aneuploidy and cumulative live birth rate: A single-center cohort study.Journal of assisted reproduction and genetics · 2026Article
- Analysis of pregnancy outcomes in patients with unexplained recurrent miscarriage assisted by IVF/ICSI with or without PGT-A.Journal of assisted reproduction and genetics · 2025Article
- Unveiling clinic variation in utilization of ICSI, PGT, and blastocyst transfer: a comprehensive study using the SART database (2014-2020).Journal of assisted reproduction and genetics · 2025Article
- Why the hypothesis of embryo selection in IVF/ICSI must finally be reconsidered.Human reproduction open · 2025Article
- Greater PGT-A utilization in IVF clinics does not improve live birth rates but relates to IVF center ownership: a preliminary report.Journal of assisted reproduction and genetics · 2025Article
- From live birth to live birth: a strong correlation between the outcomes of first and second frozen-thawed euploid blastocyst transfers from sibling oocytes.Journal of assisted reproduction and genetics · 2025Article
- Basal FSH values are positively associated with aneuploidy incidence in pre-advanced maternal age (AMA) but not in AMA patients.Journal of assisted reproduction and genetics · 2024Article
- Acupuncture improves the live birth of patients with repeated implantation failure: a retrospective cohort study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Viewing early life without labels: optical approaches for imaging the early embryo†.Biology of reproduction · 2024Review
- Extracellular vesicles secreted by human aneuploid embryos present a distinct transcriptomic profile and upregulate MUC1 transcription in decidualised endometrial stromal cells.Human reproduction open · 2024Article
- Live birth rates in in vitro fertilization cycles with five or fewer follicles.Journal of assisted reproduction and genetics · 2024Article
- Current Applications and Controversies in Preimplantation Genetic Testing for Aneuploidies (PGT-A) in In Vitro Fertilization.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Comparison of 1-year cumulative live birth and perinatal outcomes following single blastocyst transfer with or without preimplantation genetic testing for aneuploidy: a propensity score-matched study.Journal of assisted reproduction and genetics · 2023Article
- Sociocultural imperatives for Singapore to permit preimplantation genetic testing-aneuploidy (PGT-A) despite uncertain results and ongoing controversy.Journal of assisted reproduction and genetics · 2023Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on cumulative live birth rate (CLBR) in IVF cycles.
methodsRetrospective cohort study of the SART CORS database, comparing CLBR for patients using autologous oocytes, with or without PGT-A. The first reported autologous ovarian stimulation cycle per patient between January 1, 2014, and December 31, 2015, and all linked embryo transfer cycles between January 1, 2014, and December 31, 2016, were included in the study. Exclusion criteria were donor oocyte cycles, donor embryo cycles, gestational carrier cycles, cycles which included both a fresh embryo transfer (ET) combined with a thawed embryo previously frozen (ET plus FET), or cycles with a fresh ET after PGT-A.
resultsA total of 133,494 autologous IVF cycles were analyzed. Amongst patients who had blastocysts available for either ET or PGT-A, including those without transferrable embryos, decreased CLBR was noted in the PGT-A group at all ages, except ages > 40 (p < 0.01). A subgroup analysis of only those patients who had PGT-A and a subsequent FET, excluding those without transferrable embryos, demonstrated a very high CLBR, ranging from 71.2% at age < 35 to 50.2% at age > 42. Rates of multiple gestations, preterm birth, early pregnancy loss, and low birth weight were all greater in the non-PGT-A group.
conclusionsPGT-A was associated with decreased CLBR amongst all patients who had blastocysts available for ET or PGT-A, except those aged > 40. The negative association of PGT-A use and CLBR per cycle start was especially pronounced at age < 35.
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