Evidence map›Paper›PMID 36454086›Full record

ArticleAmerican journal of respiratory cell and molecular biology2022

Elexacaftor/Tezacaftor/Ivacaftor Disrupts Respiratory Tract Development in a Murine Fetal Lung Explant Model.

Mickaël Lhuillier, Laura Aoust, Elise Dreano, Marie-Laure Franco-Montoya, Kim Landry-Truchon, Nicolas Houde, Stéphanie Chhun, Alexandre Hinzpeter, Aleksander Edelman, Christophe Delacourt and 3 more

Open access · hybridAbstract readLetter
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. A therapeutic revolution: CFTR modulators in cystic fibrosis and their impacts on pregnant women and the fetus.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Mickaël LhuillierInstitut Necker Enfants Malades Paris, France.
Laura AoustInstitut Necker Enfants Malades Paris, France.
Elise DreanoInstitut Necker Enfants Malades Paris, France.
Marie-Laure Franco-MontoyaInstitut Mondor de Recherche Biomédicale Créteil, France.
Kim Landry-TruchonCentre de Recherche du CHU de Québec-Université Laval (Oncology Axis) Québec, Canada.
Nicolas HoudeCentre de Recherche du CHU de Québec-Université Laval (Oncology Axis) Québec, Canada.
Stéphanie ChhunUniversité de Paris Paris, France.
Alexandre HinzpeterInstitut Necker Enfants Malades Paris, France.
Aleksander EdelmanInstitut Necker Enfants Malades Paris, France.
Christophe DelacourtInstitut Necker Enfants Malades Paris, France.
Lucie JeannotteCentre de Recherche du CHU de Québec-Université Laval (Oncology Axis) Québec, Canada.
Isabelle Sermet-GaudelusInstitut Necker Enfants Malades Paris, France.
Alice HadchouelInstitut Necker Enfants Malades Paris, France.
Institut Necker Enfants Malades · FRCentre hospitalier de l'Université Laval · CALaboratoire National de Référence · MAInstitut Mondor de Recherche Biomédicale · FRSorbonne Paris Cité · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

LungPyrazolesAminophenolsAnimalsBenzodioxolesIndolesMicePyridinesPyrrolidinesQuinolonesAminophenolsBenzodioxoleselexacaftorIndolesivacaftorPyrazolesPyridinesPyrrolidinesQuinolonestezacaftor

Identifiers

PMID36454086
PMCPMC9743190
OpenAlexW4311064794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.