Evidence map›Paper›PMID 36454084›Full record

ArticleAmerican journal of respiratory cell and molecular biology2022

Leptin-loaded Extracellular Vesicles Treat Sleep-disordered Breathing in Mice with Obesity.

Carla Freire, Jacob D Ramsey, Huy Pho, Ryo Kojima, Yuling Zhao, Lenise Kim, Frederick Anokye-Danso, Slava Berger, Rexford S Ahima, Elena V Batrakova and 2 more

Open access · hybridAbstract readLetter
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Carla FreireThe Johns Hopkins School of Medicine Baltimore, Maryland.
Jacob D RamseyUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Huy PhoThe Johns Hopkins School of Medicine Baltimore, Maryland.
Ryo KojimaUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Yuling ZhaoUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Lenise KimThe Johns Hopkins School of Medicine Baltimore, Maryland.
Frederick Anokye-DansoThe Johns Hopkins School of Medicine Baltimore, Maryland.
Slava BergerThe Johns Hopkins School of Medicine Baltimore, Maryland.ORCID 0000-0001-6188-0118
Rexford S AhimaThe Johns Hopkins School of Medicine Baltimore, Maryland.
Elena V BatrakovaUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Alexander V KabanovUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Vsevolod Y PolotskyThe Johns Hopkins School of Medicine Baltimore, Maryland.ORCID 0000-0002-2951-7535
Johns Hopkins University · USUniversity of North Carolina at Chapel Hill · US

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1M
Treatment of Sleep Apnea by Targeting Leptin SignalingR01HL128970 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MENDELOWITZ, DAVID, POLOTSKY, VSEVOLOD Y · 2015 to 2023
$5.4M
Chemogenetic approach to treat Obstructive Sleep ApneaR01HL138932 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2017 to 2020
$2.4M
Extracellular Vesicles for CNS Delivery of Therapeutic Enzymes to Treat Lysosomal Storage DisordersR01NS112019 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATRAKOVA, ELENA · 2019 to 2023
$1.5M
Intranasal Leptin as A Novel Treatment of Opioid-Induced Respiratory DepressionR61HL156240 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2020 to 2020
$737k
Targeting Leptin Pathway to Treat Opioid-Induced Respiratory DepressionU18DA052301 · NIDA · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2021 to 2021
$259k
NHLBI NIH HHS R01 HL128970NHLBI NIH HHS R01 HL133100NHLBI NIH HHS R01 HL138932NHLBI NIH HHS R61 HL156240NIDA NIH HHS U18 DA052301NIH HHS R01HL128970NIH HHS R01HL133100NIH HHS R01HL138932NIH HHS R01NS112019NIH HHS R61HL156240NIH HHS U18DA052301NINDS NIH HHS R01 NS112019
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Extracellular VesiclesSleep Apnea SyndromesAnimalsLeptinMiceObesityLeptin

Identifiers

PMID36454084
PMCPMC9743189
OpenAlexW4311064264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.