Evidence map›Paper›PMID 36453908›Full record

ArticleMicrobiology spectrum2022

Rational Design of Live-Attenuated Vaccines against Genome-Reduced Pathogens.

Sayaka Nishikawa, Yohsuke Ogawa, Kazumasa Shiraiwa, Rieko Nozawa, Momoko Nakayama, Masahiro Eguchi, Yoshihiro Shimoji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sayaka NishikawaNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.
Yohsuke OgawaNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.
Kazumasa ShiraiwaNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.
Rieko NozawaNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.
Momoko NakayamaNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.
Masahiro EguchiNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.
Yoshihiro ShimojiNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan.ORCID 0000-0003-1107-6134
National Agriculture and Food Research Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To develop safe and highly effective live vaccines, rational vaccine design is necessary. Here, we sought a simple approach to rationally develop a safe attenuated vaccine against the genome-reduced pathogen Erysipelothrix rhusiopathiae. We examined the mRNA expression of all conserved amino acid biosynthetic genes remaining in the genome after the reductive evolution of

Indexed as

ErysipelothrixAnimalsBacterial VaccinesMacrophagesMiceSwineVaccines, AttenuatedBacterial VaccinesVaccines, AttenuatedErysipelothrix rhusiopathiaegenome-reduced bacteriametabolic adaptationvaccine design

Identifiers

PMID36453908
PMCPMC9769512
OpenAlexW4310570502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.