ArticleFrontiers in microbiology2022
Cutaneous dysbiosis may amplify barrier dysfunction in patients with atopic dermatitis.
Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Effectiveness and Tolerability of an Emollient "Plus" Compared to Urea 10% in Patients With Mild-to-Moderate Atopic Dermatitis.Journal of cosmetic dermatology · 2025Trial
- The Effectiveness of Allergen Immunotherapy in Adult Patients with Atopic Dermatitis Allergic to House Dust Mites.Medicina (Kaunas, Lithuania) · 2022Trial
- Epithelial-Dermal Immune Memory: TrackingInternational journal of molecular sciences · 2026Review
- Reframing Eczema: Th2-Skewed Contact Sensitization, Atopy Patch Testing, and Systemic Contact Dermatitis.Current allergy and asthma reports · 2026Review
- Allergic-related skin diseases: Global disease burden from 1990 to 2021 and future trends.The World Allergy Organization journal · 2025Article
- The Skin Mycobiome of Patients With Atopic Dermatitis and Healthy Volunteers: A Case-Control Study.Experimental dermatology · 2025Article
- The Neuroimmune Axis in Atopic Dermatitis: From Pathogenic Mechanisms to Targeted Neuroimmunotherapy.Journal of inflammation research · 2025Review
- Dupilumab as an innovative therapy for symptomatic management of chemotherapy-induced pruritus: A case series.Skin health and disease · 2024Article
- Polymorphic markers of several immune regulatory genes modulate the susceptibility for eczema and related phenotypes in children.Translational pediatrics · 2024Article
- Understanding the role ofFrontiers in medicine · 2024Review
- The economic burden of atopic dermatitis in Romania: a broad perspective.Frontiers in public health · 2024Article
- Skin microbiota: pathogenic roles and implications in atopic dermatitis.Frontiers in cellular and infection microbiology · 2024Review
- Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis: An Italian Real-Life, Multicenter, Retrospective, Observational Study.Medicina (Kaunas, Lithuania) · 2023Observational
- Fungal dysbiosis and decreased tear mucin at the conjunctiva in patients with conjunctival mucosa-associated lymphoid tissue lymphoma.BMJ open ophthalmology · 2023Article
- Atopic Dermatitis and Ulcerative Colitis Successfully Treated with Upadacitinib.Medicina (Kaunas, Lithuania) · 2023Article
- Analysis of Adverse Reactions of Cosmetics in Chinese Han Population in Recent Five Years.Clinical, cosmetic and investigational dermatology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic dermatitis (AD) is associated with cutaneous dysbiosis, barrier defects, and immune dysregulation, but the interplay between these factors needs further study. Early-onset barrier dysfunction may facilitate an innate immune response to commensal organisms and, consequently, the development of allergic sensitization. We aimed to compare the cutaneous microbiome in patients with active dermatitis with and without a history of childhood flexural dermatitis (atopic dermatitis). Next-gen Ion-Torrent deep-sequencing identified AD-associated changes in the skin bacterial microbiome ("bacteriome") and fungal microbiome ("mycobiome") of affected skin in swabs from areas of skin affected by dermatitis. Data were analyzed for diversity, abundance, and inter-kingdom correlations. Microbial interactions were assessed in biofilms using metabolic activity (XTT) assay and scanning electron microscopy (SEM), while host-pathogen interactions were determined in cultured primary keratinocytes exposed to biofilms. Increased richness and abundance of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.