Evidence map›Paper›PMID 36452875›Full record

ArticleCell reports methods2022

Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation.

Atagun U Isiktas, Aziz Eshov, Suzhou Yang, Junjie U Guo

Abstract read
In one paragraph

Article in Cell reports methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Technologies for engineering repetitive DNA.Quantitative biology (Beijing, China) · 2026
    Review
  2. Microprotein Regulates G-quadruplex Driven RNA Aggregation.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Odd-even disparity in the population of slipped hairpins in RNA repeat sequences with implications for phase separation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Atagun U IsiktasDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Aziz EshovDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Suzhou YangDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Junjie U GuoDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.

Funding

Molecular and cellular determinants of RNA repeat-associated propertiesDP2GM132930 · NIGMS · YALE UNIVERSITY · PI GUO, JUNJIE · 2018 to 2018
$2.5M
NIGMS NIH HHS DP2 GM132930
6 · The paper itself

Abstract

A common pathological feature of RNAs containing expanded repeat sequences is their propensity to aggregate in cells. While some repeat RNA aggregates have been shown to cause toxicity by sequestering RNA-binding proteins, the molecular mechanism of aggregation remains unclear. Here, we devised an efficient method to generate long tandem repeat DNAs

Indexed as

RNATandem Repeat SequencesBase PairingRNAG-quadruplexmicrosatellitemultivalent interactionsrepeat expansion disorderRNA aggregationRNA base-pairingRNA imagingRNA structureshort tandem repeat

Identifiers

PMID36452875
PMCPMC9701603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.