Evidence map›Paper›PMID 36452870›Full record

ArticleCell reports methods2022

A high-throughput electron tomography workflow reveals over-elongated centrioles in relapsed/refractory multiple myeloma.

Tobias Dittrich, Sebastian Köhrer, Martin Schorb, Isabella Haberbosch, Mandy Börmel, Hartmut Goldschmidt, Gabor Pajor, Carsten Müller-Tidow, Marc S Raab, Ute Hegenbart and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Theranostics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Tobias DittrichClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Sebastian KöhrerClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Martin SchorbElectron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
Isabella HaberboschClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Mandy BörmelElectron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
Hartmut GoldschmidtDepartment of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Gabor PajorClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Carsten Müller-TidowDepartment of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Marc S RaabClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Ute HegenbartDepartment of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Stefan O SchönlandDepartment of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
Yannick SchwabCell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany.
Alwin KrämerClinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.
German Cancer Research Center · DEHeidelberg University · DEEuropean Molecular Biology Laboratory · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electron microscopy is the gold standard to characterize centrosomal ultrastructure. However, production of significant morphometrical data is highly limited by acquisition time. We therefore developed a generalizable, semi-automated high-throughput electron tomography strategy to study centrosome aberrations in sparse patient-derived cancer cells at nanoscale. As proof of principle, we present electron tomography data on 455 centrioles of CD138

Indexed as

CentriolesMultiple MyelomaCentrosomeElectron Microscope TomographyHumansWorkflowbone marrowcentriole fragmentationcentriole over-elongationcentrosomeelectron tomographyhigh-throughput electron microscopymultiple myelomaplasma cell disorder

Identifiers

PMID36452870
PMCPMC9701608
OpenAlexW4308036525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.