Evidence map›Paper›PMID 36452504›Full record

ArticleFrontiers in oncology2022

Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD.

Marie Schwarz, Sophie Rizzo, Walter Espinoza Paz, Anne Kresinsky, Damien Thévenin, Jörg P Müller

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Marie SchwarzInstitute for Molecular Cell Biology, CMB - Center for Molecular Biomedicine, University Hospital Jena, Jena, Germany.
Sophie RizzoDepartment of Chemistry, Lehigh University, Bethlehem, PA, United States.
Walter Espinoza PazDepartment of Chemistry, Lehigh University, Bethlehem, PA, United States.
Anne KresinskyInstitute for Molecular Cell Biology, CMB - Center for Molecular Biomedicine, University Hospital Jena, Jena, Germany.
Damien ThéveninDepartment of Chemistry, Lehigh University, Bethlehem, PA, United States.
Jörg P MüllerInstitute for Molecular Cell Biology, CMB - Center for Molecular Biomedicine, University Hospital Jena, Jena, Germany.
Jena University Hospital · DELehigh University · US

Funding

Promoting Receptor Protein Tyrosine Phosphatase Activity by TargetingTransmembrane Domain InteractionsR01GM139998 · NIGMS · LEHIGH UNIVERSITY · PI LAZZARA, MATTHEW J, THEVENIN, DAMIEN · 2020 to 2023
$1.7M
NIGMS NIH HHS R01 GM139998
6 · The paper itself

Abstract

The receptor protein tyrosine phosphatase (RPTP) PTPRJ (also known as DEP-1) has been identified as a negative regulator of the receptor tyrosine kinase FLT3 signalling

Indexed as

AMLDEP-1oncogenic FLT3 ITDreceptor protein tyrosine phosphatase (RPTP)receptor tyrosine kinase (RTK)signal transductiontransmembrane domain oligomerization

Identifiers

PMID36452504
PMCPMC9701752
OpenAlexW4309043483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.