Evidence map›Paper›PMID 36452458›Full record

ArticleFrontiers in molecular biosciences2022

Deficiency in ST6GAL1, one of the two α2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease.

Natallia Makarava, Elizaveta Katorcha, Jennifer Chen-Yu Chang, Joseph T Y Lau, Ilia V Baskakov

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Natallia MakaravaCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
Elizaveta KatorchaCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
Jennifer Chen-Yu ChangCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
Joseph T Y LauDepartment of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Ilia V BaskakovCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · USRoswell Park Comprehensive Cancer Center · US

Funding

Project 3: Role of Glycosaminoglycans in HematopoiesisP01HL151333 · NHLBI · VERSITI WISCONSIN, INC. · PI HOFFMEISTER, KARIN MARIA · 2021 to 2025
$12.3M
Self-Propagating Mechanism of Prion DiseasesR01NS045585 · NINDS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI Ilia V Baskakov · 2003 to 2026
$9.6M
ST6Gal-1 Sialyltransferase in InflammationR01AI140736 · NIAID · ROSWELL PARK CANCER INSTITUTE CORP · PI LAU, JOSEPH TY · 2018 to 2021
$3.9M
Role of prion protein sialylation in prion diseasesR01AI128925 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BASKAKOV, ILIA V · 2017 to 2020
$3.2M
NHLBI NIH HHS P01 HL151333NIAID NIH HHS R01 AI128925NIAID NIH HHS R01 AI140736NINDS NIH HHS R01 NS045585
6 · The paper itself

Abstract

Prion diseases are a group of fatal neurodegenerative diseases caused by misfolding of the normal cellular form of the prion protein or PrP

Indexed as

mouseN-glycosylationprionprion diseasessialic acidsialyltransferasesST6GAL1ST6GAL2

Identifiers

PMID36452458
PMCPMC9702343
OpenAlexW4309011380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.