Evidence map›Paper›PMID 36452451›Full record

ArticleFrontiers in molecular biosciences2022

Polyanion order controls liquid-to-solid phase transition in peptide/nucleic acid co-assembly.

Christella Gordon-Kim, Allisandra Rha, George A Poppitz, Jillian Smith-Carpenter, Regina Luu, Alexis B Roberson, Russell Conklin, Alexis Blake, David G Lynn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Christella Gordon-KimDepartment of Chemistry, Emory University, Atlanta, GA, United States.
Allisandra RhaChildren's Health of Orange County, Research Institute, Orange, CA, United States.
George A PoppitzDepartment of Chemistry, Emory University, Atlanta, GA, United States.
Jillian Smith-CarpenterDepartment of Chemistry, Emory University, Atlanta, GA, United States.
Regina LuuDepartment of Chemistry, Emory University, Atlanta, GA, United States.
Alexis B RobersonDepartment of Chemistry, Emory University, Atlanta, GA, United States.
Russell ConklinDepartment of Chemistry, Emory University, Atlanta, GA, United States.
Alexis BlakeDepartment of Chemistry, Emory University, Atlanta, GA, United States.
David G LynnDepartment of Chemistry, Emory University, Atlanta, GA, United States.
Emory University · USChildren's Hospital of Orange County · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Central Dogma highlights the mutualistic functions of protein and nucleic acid biopolymers, and this synergy appears prominently in the membraneless organelles widely distributed throughout prokaryotic and eukaryotic organisms alike. Ribonucleoprotein granules (RNPs), which are complex coacervates of RNA with proteins, are a prime example of these membranelles organelles and underly multiple essential cellular functions. Inspired by the highly dynamic character of these organelles and the recent studies that ATP both inhibits and templates phase separation of the fused in sarcoma (FUS) protein implicated in several neurodegenerative diseases, we explored the RNA templated ordering of a single motif of the Aβ peptide of Alzheimer's disease. We now know that this strong cross-

Indexed as

amyloid plasticitynucleation and propagation of paracrystalline assembliessystems analyses of co-assemblysystems chemistrytemplated co-assemblytemplating cross-β peptide architectures with nucleic acids

Identifiers

PMID36452451
PMCPMC9702359
OpenAlexW4308974681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.