Evidence map›Paper›PMID 36452329›Full record

ArticleFrontiers in endocrinology2022

Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta.

Helena Fabiana Forte-Gomez, Roberta Gioia, Francesca Tonelli, Birgit Kobbe, Peter Koch, Wilhelm Bloch, Mats Paulsson, Frank Zaucke, Antonella Forlino, Raimund Wagener

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Helena Fabiana Forte-GomezCenter for Biochemistry, University of Cologne, Cologne, Germany.
Roberta GioiaDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
Francesca TonelliDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
Birgit KobbeCenter for Biochemistry, University of Cologne, Cologne, Germany.
Peter KochDepartment of Pharmacology, University Clinic Cologne, Cologne, Germany.
Wilhelm BlochInstitute of Cardiovascular Research and Sport Medicine, German Sport University, Cologne, Germany.
Mats PaulssonCenter for Biochemistry, Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Frank ZauckeDr. Rolf M. Schwiete Research Unit for Osteoarthritis, Department of Orthopedics (Friedrichsheim), University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Antonella ForlinoDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy.
Raimund WagenerCenter for Biochemistry, Center for Molecular Medicine, University of Cologne, Cologne, Germany.
University of Cologne · DEUniversity of Pavia · ITGerman Sport University Cologne · DEOrthopaedic University Hospital Friedrichsheim · DEUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COMP (Cartilage Oligomeric Matrix Protein), also named thrombospondin-5, is a member of the thrombospondin family of extracellular matrix proteins. It is of clinical relevance, as in humans mutations in COMP lead to chondrodysplasias. The gene encoding zebrafish Comp is located on chromosome 11 in synteny with its mammalian orthologs. Zebrafish Comp has a domain structure identical to that of tetrapod COMP and shares 74% sequence similarity with murine COMP. Zebrafish

Indexed as

CRISPR-Cas SystemsZebrafishAdultAnimalsCartilage Oligomeric Matrix ProteinHumansMammalsMicePhenotypeThrombospondinsCartilage Oligomeric Matrix ProteinThrombospondinschondrodysplasiacompextracellular matrixthrombospondinszebrafish

Identifiers

PMID36452329
PMCPMC9702538
OpenAlexW4309011386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.