Evidence map›Paper›PMID 36451848›Full record

ArticleERJ open research2022

AROMA: real-world global registry of dupilumab for chronic rhinosinusitis with nasal polyps.

Shahid Siddiqui, Claus Bachert, Adam M Chaker, Joseph K Han, Peter W Hellings, Anju T Peters, Enrico Heffler, Siddhesh Kamat, Haixin Zhang, Scott Nash and 5 more

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Visual and bibliometric analysis of chronic rhinosinusitis and nasal polyps.The journal of allergy and clinical immunology. Global · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 8 countries.

Shahid SiddiquiMedical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Claus BachertUpper Airways Research Laboratory and Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.
Adam M ChakerTUM Medical School, Klinikum rechts der Isar, Department of Otolaryngology and ZAUM, Technical University of Munich, Munich, Germany.
Joseph K HanDepartment of Otolaryngology and Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, VA, USA.
Peter W HellingsUpper Airways Research Laboratory and Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.
Anju T PetersDivision of Allergy and Immunology and Sinus and Allergy Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID https://orcid.org/0000-0003-0745-2379
Enrico HefflerAllergy and Respiratory Diseases, Humanitas Clinical and Research Center IRCCS, Milan, Italy.
Siddhesh KamatMedical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Haixin ZhangMedical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Scott NashMedical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Asif H KhanGlobal Medical Affairs, Sanofi, Chilly-Mazarin, France.ORCID https://orcid.org/0000-0001-9158-0116
Lucia De Prado GomezGlobal Medical Affairs, Sanofi, Reading, UK.ORCID https://orcid.org/0000-0002-9464-2201
Juby A Jacob-NaraGlobal Medical Affairs, Sanofi, Bridgewater, NJ, USA.
Paul J RoweGlobal Medical Affairs, Sanofi, Bridgewater, NJ, USA.
Yamo DenizMedical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Regeneron (United States) · USSanofi (United States) · USEastern Virginia Medical School · USGhent University · BEHumanitas University · ITNorthwestern University · USSanofi (France) · FRSanofi (United Kingdom) · GBSun Yat-sen University · CNTUM Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammatory disease of the nasal and paranasal sinuses. Dupilumab is a monoclonal antibody that blocks the shared receptor component for interleukin-4 and interleukin-13, which are key and central drivers of type 2 inflammation. In clinical trials, dupilumab significantly improved objective and patient-reported measures of CRSwNP

Identifiers

PMID36451848
PMCPMC9703146
OpenAlexW4307639955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.