Evidence map›Paper›PMID 36451824›Full record

ArticleFrontiers in immunology2022

Cytokine expression in rhinovirus- vs. respiratory syncytial virus-induced first wheezing episode and its relation to clinical course.

Pekka Hurme, Miisa Komulainen, Marleena Tulkki, Annamari Leino, Beate Rückert, Riitta Turunen, Tytti Vuorinen, Mübeccel Akdis, Cezmi A Akdis, Tuomas Jartti

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Viral and Host-Related Factors in the Nasal Inflammatory Response to Critical Bronchiolitis in Infants and Children.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Pekka HurmeDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Miisa KomulainenDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Marleena TulkkiDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Annamari LeinoDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Beate RückertSwiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
Riitta TurunenDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Tytti VuorinenInstitute of Biomedicine, University of Turku, Turku, Finland.
Mübeccel AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
Tuomas JarttiDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
University of Turku · FICK-CARE · CHTurku University Hospital · FIOulu University Hospital · FIUniversity of Helsinki · FIUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhinovirus (RV) and respiratory syncytial virus (RSV) are common causes of bronchiolitis. Unlike an RSV etiology, an RV etiology is associated with a markedly increased risk of asthma. We investigated the cytokine profiles of RV- and RSV-induced first wheezing episode and their correlation with prognosis. We recruited 52 sole RV- and 11 sole RSV-affected children with a severe first wheezing episode. Peripheral blood mononuclear cells (PBMCs) were isolated during acute illness and 2 weeks later and stimulated

Indexed as

Enterovirus InfectionsPneumovirusRespiratory Syncytial Virus, HumanChemokine CX3CL1ChildCytokinesHumansInterleukin 1 Receptor Antagonist ProteinInterleukin-6Leukocytes, MononuclearRecurrenceRespiratory SoundsRhinovirusVascular Endothelial Growth Factor AChemokine CX3CL1CytokinesInterleukin 1 Receptor Antagonist ProteinInterleukin-6Vascular Endothelial Growth Factor Abronchiolitiscytokinerespiratory syncytial virusrhinoviruswheezing

Identifiers

PMID36451824
PMCPMC9702984
OpenAlexW4309010546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.